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Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies
Acute kidney injury (AKI) is a known risk factor for chronic kidney disease (CKD) and end stage kidney disease (ESKD). The progression from AKI to CKD, despite being well recognised, is not completely understood, although sustained inflammation and fibrosis are implicated. A therapeutic intervention...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585193/ https://www.ncbi.nlm.nih.gov/pubmed/33097033 http://dx.doi.org/10.1186/s12882-020-02098-9 |
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author | Asad, Anam Burton, James O. March, Daniel S. |
author_facet | Asad, Anam Burton, James O. March, Daniel S. |
author_sort | Asad, Anam |
collection | PubMed |
description | Acute kidney injury (AKI) is a known risk factor for chronic kidney disease (CKD) and end stage kidney disease (ESKD). The progression from AKI to CKD, despite being well recognised, is not completely understood, although sustained inflammation and fibrosis are implicated. A therapeutic intervention targeting the post AKI stage could reduce the progression to CKD, which has high levels of associated morbidity and mortality. Exercise has known anti-inflammatory effects with animal AKI models demonstrating its use as a therapeutic agent in abrogating renal injury. This suggests the use of an exercise rehabilitation programme in AKI patients following discharge could attenuate renal damage and improve long term patient outcomes. In this review article we outline considerations for future clinical studies of exercise in the AKI population. |
format | Online Article Text |
id | pubmed-7585193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75851932020-10-26 Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies Asad, Anam Burton, James O. March, Daniel S. BMC Nephrol Review Acute kidney injury (AKI) is a known risk factor for chronic kidney disease (CKD) and end stage kidney disease (ESKD). The progression from AKI to CKD, despite being well recognised, is not completely understood, although sustained inflammation and fibrosis are implicated. A therapeutic intervention targeting the post AKI stage could reduce the progression to CKD, which has high levels of associated morbidity and mortality. Exercise has known anti-inflammatory effects with animal AKI models demonstrating its use as a therapeutic agent in abrogating renal injury. This suggests the use of an exercise rehabilitation programme in AKI patients following discharge could attenuate renal damage and improve long term patient outcomes. In this review article we outline considerations for future clinical studies of exercise in the AKI population. BioMed Central 2020-10-23 /pmc/articles/PMC7585193/ /pubmed/33097033 http://dx.doi.org/10.1186/s12882-020-02098-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Asad, Anam Burton, James O. March, Daniel S. Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title | Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title_full | Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title_fullStr | Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title_full_unstemmed | Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title_short | Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
title_sort | exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585193/ https://www.ncbi.nlm.nih.gov/pubmed/33097033 http://dx.doi.org/10.1186/s12882-020-02098-9 |
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