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Implication of Microsatellite Instability in Chinese Cohort of Human Cancers

BACKGROUND: Microsatellite instability (MSI) has been a hot topic in cancer research. Determining MSI status greatly aids tumor prognosis and treatment plans. However, MSI data for Asian cancer patients with prognostic information are scarce. Here, our aim was to clarify MSI status and its prognosti...

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Autores principales: Cui, Meiying, Li, Pan, Mao, Ying, Zhang, Lan, Xia, Peiyi, Liu, Enjie, Wang, Weiwei, Zhang, Jianying, Jiang, Guozhong, Li, Wencai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585277/
https://www.ncbi.nlm.nih.gov/pubmed/33116883
http://dx.doi.org/10.2147/CMAR.S274187
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author Cui, Meiying
Li, Pan
Mao, Ying
Zhang, Lan
Xia, Peiyi
Liu, Enjie
Wang, Weiwei
Zhang, Jianying
Jiang, Guozhong
Li, Wencai
author_facet Cui, Meiying
Li, Pan
Mao, Ying
Zhang, Lan
Xia, Peiyi
Liu, Enjie
Wang, Weiwei
Zhang, Jianying
Jiang, Guozhong
Li, Wencai
author_sort Cui, Meiying
collection PubMed
description BACKGROUND: Microsatellite instability (MSI) has been a hot topic in cancer research. Determining MSI status greatly aids tumor prognosis and treatment plans. However, MSI data for Asian cancer patients with prognostic information are scarce. Here, our aim was to clarify MSI status and its prognostic value in a large Chinese cohort with different tumors. PATIENTS AND METHODS: Tissue samples from 600 Chinese cases, including 150 endometrial cancers, 150 colorectal cancers, 150 liver cancers and 150 gastric cancers, were used for IHC and MSI examinations. Two mononucleotide and three dinucleotide markers were used to analyze MSI status. RESULTS: In total,17.3% (26/150) of endometrial cancer patients showed positive MSI,10.0% (15/150) in colorectal cancer, 2.7% (4/150) in liver cancer, and 2.7% (4/150) in gastric cancer. Tumor location (P < 0.001 for colorectal cancer) and clinical stage (P =0.038 for gastric cancer) showed significant correlations with MSI status in gastrointestinal carcinogenesis. The mismatch repair (MMR) deficiency was observed in 20 colorectal cases (13.3%) and was significantly more frequent in the MSI-positive group (P < 0.001). Interestingly, the prevalence of MSI-H was mostly occurred in early-stage tumors, and none was in late stage (stage IV). Meanwhile, low clinicopathological stage had significant correlation with longer survival in multiple cancers here. CONCLUSION: The incidence of microsatellite instability varies among different cancer types. And the prevalence of MSI-H mostly occurred early clinicopathological stage. In addition, our study provided a large Asian cohort screened by five loci PCR method and significantly increased knowledge on the prognostic significance of MSI in Asia.
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spelling pubmed-75852772020-10-27 Implication of Microsatellite Instability in Chinese Cohort of Human Cancers Cui, Meiying Li, Pan Mao, Ying Zhang, Lan Xia, Peiyi Liu, Enjie Wang, Weiwei Zhang, Jianying Jiang, Guozhong Li, Wencai Cancer Manag Res Original Research BACKGROUND: Microsatellite instability (MSI) has been a hot topic in cancer research. Determining MSI status greatly aids tumor prognosis and treatment plans. However, MSI data for Asian cancer patients with prognostic information are scarce. Here, our aim was to clarify MSI status and its prognostic value in a large Chinese cohort with different tumors. PATIENTS AND METHODS: Tissue samples from 600 Chinese cases, including 150 endometrial cancers, 150 colorectal cancers, 150 liver cancers and 150 gastric cancers, were used for IHC and MSI examinations. Two mononucleotide and three dinucleotide markers were used to analyze MSI status. RESULTS: In total,17.3% (26/150) of endometrial cancer patients showed positive MSI,10.0% (15/150) in colorectal cancer, 2.7% (4/150) in liver cancer, and 2.7% (4/150) in gastric cancer. Tumor location (P < 0.001 for colorectal cancer) and clinical stage (P =0.038 for gastric cancer) showed significant correlations with MSI status in gastrointestinal carcinogenesis. The mismatch repair (MMR) deficiency was observed in 20 colorectal cases (13.3%) and was significantly more frequent in the MSI-positive group (P < 0.001). Interestingly, the prevalence of MSI-H was mostly occurred in early-stage tumors, and none was in late stage (stage IV). Meanwhile, low clinicopathological stage had significant correlation with longer survival in multiple cancers here. CONCLUSION: The incidence of microsatellite instability varies among different cancer types. And the prevalence of MSI-H mostly occurred early clinicopathological stage. In addition, our study provided a large Asian cohort screened by five loci PCR method and significantly increased knowledge on the prognostic significance of MSI in Asia. Dove 2020-10-19 /pmc/articles/PMC7585277/ /pubmed/33116883 http://dx.doi.org/10.2147/CMAR.S274187 Text en © 2020 Cui et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Cui, Meiying
Li, Pan
Mao, Ying
Zhang, Lan
Xia, Peiyi
Liu, Enjie
Wang, Weiwei
Zhang, Jianying
Jiang, Guozhong
Li, Wencai
Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title_full Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title_fullStr Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title_full_unstemmed Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title_short Implication of Microsatellite Instability in Chinese Cohort of Human Cancers
title_sort implication of microsatellite instability in chinese cohort of human cancers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585277/
https://www.ncbi.nlm.nih.gov/pubmed/33116883
http://dx.doi.org/10.2147/CMAR.S274187
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