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Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1

Neddylation is a process by which NEDD8 is covalently conjugated to target proteins by sequential enzymatic reaction. Its role in cancer cell migration has only been recently acknowledged. Previously in cancer cell migration, the epithelial to mesenchymal transition (EMT) process has been well-known...

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Detalles Bibliográficos
Autores principales: Park, Jun Bum, Seo, Jieun, Park, Jong-Wan, Chun, Yang-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585416/
https://www.ncbi.nlm.nih.gov/pubmed/33097763
http://dx.doi.org/10.1038/s41598-020-75286-0