Cargando…

Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1

Neddylation is a process by which NEDD8 is covalently conjugated to target proteins by sequential enzymatic reaction. Its role in cancer cell migration has only been recently acknowledged. Previously in cancer cell migration, the epithelial to mesenchymal transition (EMT) process has been well-known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jun Bum, Seo, Jieun, Park, Jong-Wan, Chun, Yang-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585416/ https://www.ncbi.nlm.nih.gov/pubmed/33097763 http://dx.doi.org/10.1038/s41598-020-75286-0

Ejemplares similares

The Effect of Neddylation Blockade on Slug-Dependent Cancer Cell Migration Is Regulated by p53 Mutation Status
por: Kim, Yelee, et al.
Publicado: (2021)

Neddylation of sterol regulatory element-binding protein 1c is a potential therapeutic target for nonalcoholic fatty liver treatment
por: Ju, Uk-Il, et al.
Publicado: (2020)

HIF-1α Upregulation due to Depletion of the Free Ubiquitin Pool
por: Kim, Jiyoung, et al.
Publicado: (2015)

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells
por: Park, Sung Yeon, et al.
Publicado: (2018)

Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration
por: Lin, Yuli, et al.
Publicado: (2021)

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
por: Bandau, Susanne, et al.
Publicado: (2012)

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys(63)-linked polyubiquitination
por: Park, Catherine V., et al.
Publicado: (2017)

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans
por: Zhang, L, et al.
Publicado: (2016)

Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells
por: Seo, Jieun, et al.
Publicado: (2020)

FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α
por: Kang, Jengmin, et al.
Publicado: (2018)

A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT
por: Mandl, M, et al.
Publicado: (2016)

Upregulation of fascin-1 is involved in HIF-1α-dependent invasion and migration of hypopharyngeal squamous cell carcinoma
por: Bu, Mingqiang, et al.
Publicado: (2019)

HIF2α Upregulates the Migration Factor ODZ1 under Hypoxia in Glioblastoma Stem Cells
por: Carcelén, María, et al.
Publicado: (2022)

The lncRNA ZEB2-AS1 is upregulated in gastric cancer and affects cell proliferation and invasion via miR-143-5p/HIF-1α axis
por: Wu, Fangxiong, et al.
Publicado: (2019)

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer
por: Zhang, Wenjing, et al.
Publicado: (2015)

UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF-1α-mediated mitophagy
por: Yan, Qiqian, et al.
Publicado: (2023)

Oxygen-dependent and -independent regulation of HIF-1alpha.
por: Chun, Yang-Sook, et al.
Publicado: (2002)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2018)

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT
por: Yoshimoto, Shohei, et al.
Publicado: (2019)

HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
por: Zhu, Jianning, et al.
Publicado: (2021)

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
por: Miska, Jason, et al.
Publicado: (2019)

Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade
por: Mickova, Alena, et al.
Publicado: (2021)

Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer
por: Jin, Yan, et al.
Publicado: (2021)

Remifentanil up‐regulates HIF1α expression to ameliorate hepatic ischaemia/reperfusion injury via the ZEB1/LIF axis
por: Zhou, Rongsheng, et al.
Publicado: (2020)

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours
por: Snell, Cameron E., et al.
Publicado: (2014)

Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria
por: Nakuluri, Krishnamurthy, et al.
Publicado: (2019)

Corrigendum: Positive Reciprocal Feedback of LncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia–Promoted Tumorigenesis and Metastasis of Pancreatic Cancer
por: Jin, Yan, et al.
Publicado: (2021)

lncRNA ZEB1-AS1 promotes migration and metastasis of bladder cancer cells by post-transcriptional activation of ZEB1
por: Zhao, Xin, et al.
Publicado: (2019)

Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis
por: Xu, Haixu, et al.
Publicado: (2022)

Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
por: Tong, Jie, et al.
Publicado: (2021)

HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin
por: Zeng, Peng, et al.
Publicado: (2019)

ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer
por: Liu, Lingjia, et al.
Publicado: (2016)

Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells
por: Khan, Muhammad Saad, et al.
Publicado: (2019)

PHRF1 promotes migration and invasion by modulating ZEB1 expression
por: Lee, Jin-Yu, et al.
Publicado: (2020)

Hif-1α provides a Twist to neural crest migration
por: Short, Ben
Publicado: (2013)

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
por: Kim, Min, et al.
Publicado: (2014)

Upregulation of LncRNA‐HIT promotes migration and invasion of non‐small cell lung cancer cells by association with ZEB1
por: Jia, Xiaojing, et al.
Publicado: (2016)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
por: Park, Mi Hee, et al.
Publicado: (2014)

Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2
por: Lee, Jae Eun, et al.
Publicado: (2019)

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
por: Li, Andrew G., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2c35o09tcvvpo15cheovgns1eo