Nanocompartments work as tiny loudspeakers to amplify cell signalling behaviour

Aberrant cell signalling has been associated with a number of diseases. Belluati and coworkers make use of dual polymer nanocompartments encapsulating different enzymes, that function in unison as in a native signalling cascade. Their functionality is integrated into native cell metabolism and physiology, using substrates already present in the extracellular medium. They succeed in amplifying a natural signalling cascade and influencing cellular homoeostasis.