Cargando…
Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study
Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity and their role in recurrent EOC are unknown. A total of 375 EOC patients were retrospectively analyzed. The correlatio...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585431/ https://www.ncbi.nlm.nih.gov/pubmed/33097745 http://dx.doi.org/10.1038/s41598-020-75316-x |
_version_ | 1783599789306281984 |
---|---|
author | Farolfi, Alberto Scarpi, Emanuela Greco, Filippo Bergamini, Alice Longo, Lucia Pignata, Sandro Casanova, Claudia Cormio, Gennaro Bologna, Alessandra Orditura, Michele Zavallone, Laura Attademo, Laura Gallà, Valentina Franzese, Elisena Pigozzi, Eva Loizzi, Vera Giorda, Giorgio Giardina, Donatella Cioffi, Raffaella De Giorgi, Ugo |
author_facet | Farolfi, Alberto Scarpi, Emanuela Greco, Filippo Bergamini, Alice Longo, Lucia Pignata, Sandro Casanova, Claudia Cormio, Gennaro Bologna, Alessandra Orditura, Michele Zavallone, Laura Attademo, Laura Gallà, Valentina Franzese, Elisena Pigozzi, Eva Loizzi, Vera Giorda, Giorgio Giardina, Donatella Cioffi, Raffaella De Giorgi, Ugo |
author_sort | Farolfi, Alberto |
collection | PubMed |
description | Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity and their role in recurrent EOC are unknown. A total of 375 EOC patients were retrospectively analyzed. The correlation between baseline NLR and SII, and platinum-free interval (PFI) according to first line bevacizumab treatment were analyzed using logistic regression analyses adjusted for baseline patient characteristics. Subsequently NLR and SII calculated before second line treatment initiation were evaluated to identify a potential correlation with progression-free survival (PFS) and overall survival (OS) in platinum-sensitive and in platinum-resistant population. In multivariate analysis, NLR ≥ 3 is an independent predictive factor for PFI at 6 months in the chemotherapy group (OR = 2.77, 95% CI 1.38–5.56, p = 0.004), not in bevacizumab treated patients. After having adjusted for ECOG performance status, histology, ascites, bevacizumab treatment at second line and BRCA status, NLR ≥ 3 and SII ≥ 730 are significantly associated with worse OS in platinum-sensitive (HR = 2.69, 95% CI 1.60–4.53, p = 0.002; HR = 2.11, 95% CI 1.29–3.43, p = 0.003, respectively), not in platinum-resistant EOC patients. Low NLR is an independent predictive factor for platinum-sensitivity in patients treated without bevacizumab. NLR and SII are prognostic factors in recurrent platinum-sensitive EOC patients. |
format | Online Article Text |
id | pubmed-7585431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75854312020-10-27 Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study Farolfi, Alberto Scarpi, Emanuela Greco, Filippo Bergamini, Alice Longo, Lucia Pignata, Sandro Casanova, Claudia Cormio, Gennaro Bologna, Alessandra Orditura, Michele Zavallone, Laura Attademo, Laura Gallà, Valentina Franzese, Elisena Pigozzi, Eva Loizzi, Vera Giorda, Giorgio Giardina, Donatella Cioffi, Raffaella De Giorgi, Ugo Sci Rep Article Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity and their role in recurrent EOC are unknown. A total of 375 EOC patients were retrospectively analyzed. The correlation between baseline NLR and SII, and platinum-free interval (PFI) according to first line bevacizumab treatment were analyzed using logistic regression analyses adjusted for baseline patient characteristics. Subsequently NLR and SII calculated before second line treatment initiation were evaluated to identify a potential correlation with progression-free survival (PFS) and overall survival (OS) in platinum-sensitive and in platinum-resistant population. In multivariate analysis, NLR ≥ 3 is an independent predictive factor for PFI at 6 months in the chemotherapy group (OR = 2.77, 95% CI 1.38–5.56, p = 0.004), not in bevacizumab treated patients. After having adjusted for ECOG performance status, histology, ascites, bevacizumab treatment at second line and BRCA status, NLR ≥ 3 and SII ≥ 730 are significantly associated with worse OS in platinum-sensitive (HR = 2.69, 95% CI 1.60–4.53, p = 0.002; HR = 2.11, 95% CI 1.29–3.43, p = 0.003, respectively), not in platinum-resistant EOC patients. Low NLR is an independent predictive factor for platinum-sensitivity in patients treated without bevacizumab. NLR and SII are prognostic factors in recurrent platinum-sensitive EOC patients. Nature Publishing Group UK 2020-10-23 /pmc/articles/PMC7585431/ /pubmed/33097745 http://dx.doi.org/10.1038/s41598-020-75316-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Farolfi, Alberto Scarpi, Emanuela Greco, Filippo Bergamini, Alice Longo, Lucia Pignata, Sandro Casanova, Claudia Cormio, Gennaro Bologna, Alessandra Orditura, Michele Zavallone, Laura Attademo, Laura Gallà, Valentina Franzese, Elisena Pigozzi, Eva Loizzi, Vera Giorda, Giorgio Giardina, Donatella Cioffi, Raffaella De Giorgi, Ugo Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title_full | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title_fullStr | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title_full_unstemmed | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title_short | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
title_sort | inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a mito24 retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585431/ https://www.ncbi.nlm.nih.gov/pubmed/33097745 http://dx.doi.org/10.1038/s41598-020-75316-x |
work_keys_str_mv | AT farolfialberto inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT scarpiemanuela inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT grecofilippo inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT bergaminialice inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT longolucia inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT pignatasandro inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT casanovaclaudia inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT cormiogennaro inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT bolognaalessandra inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT ordituramichele inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT zavallonelaura inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT attademolaura inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT gallavalentina inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT franzeseelisena inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT pigozzieva inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT loizzivera inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT giordagiorgio inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT giardinadonatella inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT cioffiraffaella inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy AT degiorgiugo inflammatoryindexesaspredictivefactorsforplatinumsensitivityandasprognosticfactorsinrecurrentepithelialovariancancerpatientsamito24retrospectivestudy |