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Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development

Thyroid-associated ophthalmopathy (TAO) is the most common extrathyroidal manifestation of toxic diffuse goiter (Graves' disease), also known as Graves' ophthalmopathy/orbitopathy. As an organ-specific autoimmune disease, the pathogenesis of TAO is still unclear. In recent years, great pro...

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Autores principales: Huang, Yazhuo, Fang, Sijie, Zhang, Shuo, Zhou, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585473/
https://www.ncbi.nlm.nih.gov/pubmed/33110747
http://dx.doi.org/10.4103/tjo.tjo_18_20
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author Huang, Yazhuo
Fang, Sijie
Zhang, Shuo
Zhou, Huifang
author_facet Huang, Yazhuo
Fang, Sijie
Zhang, Shuo
Zhou, Huifang
author_sort Huang, Yazhuo
collection PubMed
description Thyroid-associated ophthalmopathy (TAO) is the most common extrathyroidal manifestation of toxic diffuse goiter (Graves' disease), also known as Graves' ophthalmopathy/orbitopathy. As an organ-specific autoimmune disease, the pathogenesis of TAO is still unclear. In recent years, great progress has been made in revealing the mechanism of TAO. Various biological and immunosuppressive agents have emerged in an endless stream, showing encouraging results. Strengthening the basic research, establishing ideal animal models, deeply understanding the pathogenesis, and developing novel targeted drugs are of great significance to guide the clinical diagnosis and management of TAO and improve the prognosis of patients.
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spelling pubmed-75854732020-10-26 Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development Huang, Yazhuo Fang, Sijie Zhang, Shuo Zhou, Huifang Taiwan J Ophthalmol Review Article Thyroid-associated ophthalmopathy (TAO) is the most common extrathyroidal manifestation of toxic diffuse goiter (Graves' disease), also known as Graves' ophthalmopathy/orbitopathy. As an organ-specific autoimmune disease, the pathogenesis of TAO is still unclear. In recent years, great progress has been made in revealing the mechanism of TAO. Various biological and immunosuppressive agents have emerged in an endless stream, showing encouraging results. Strengthening the basic research, establishing ideal animal models, deeply understanding the pathogenesis, and developing novel targeted drugs are of great significance to guide the clinical diagnosis and management of TAO and improve the prognosis of patients. Wolters Kluwer - Medknow 2020-07-17 /pmc/articles/PMC7585473/ /pubmed/33110747 http://dx.doi.org/10.4103/tjo.tjo_18_20 Text en Copyright: © 2020 Taiwan J Ophthalmol http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Huang, Yazhuo
Fang, Sijie
Zhang, Shuo
Zhou, Huifang
Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title_full Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title_fullStr Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title_full_unstemmed Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title_short Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
title_sort progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585473/
https://www.ncbi.nlm.nih.gov/pubmed/33110747
http://dx.doi.org/10.4103/tjo.tjo_18_20
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