Cargando…
Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children
BACKGROUND: Little is known about mucocutaneous disease in acutely ill children and adolescents with COVID-19 and multisystem inflammatory syndrome in children (MIS-C). OBJECTIVE: To characterize mucocutaneous disease and its relation to clinical course among hospitalized patients with COVID-19 and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
by the American Academy of Dermatology, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585496/ https://www.ncbi.nlm.nih.gov/pubmed/33323343 http://dx.doi.org/10.1016/j.jaad.2020.10.060 |
_version_ | 1783599804353347584 |
---|---|
author | Rekhtman, Sergey Tannenbaum, Rachel Strunk, Andrew Birabaharan, Morgan Wright, Shari Garg, Amit |
author_facet | Rekhtman, Sergey Tannenbaum, Rachel Strunk, Andrew Birabaharan, Morgan Wright, Shari Garg, Amit |
author_sort | Rekhtman, Sergey |
collection | PubMed |
description | BACKGROUND: Little is known about mucocutaneous disease in acutely ill children and adolescents with COVID-19 and multisystem inflammatory syndrome in children (MIS-C). OBJECTIVE: To characterize mucocutaneous disease and its relation to clinical course among hospitalized patients with COVID-19 and MIS-C. METHODS: Descriptive cohort study of prospectively and consecutively hospitalized eligible patients between May 11, 2020 and June 5, 2020. RESULTS: In COVID-19 patients, 4 of 12 (33%) had rash and/or mucositis, including erythema, morbilliform pattern, and lip mucositis. In MIS-C patients, 9 of 19 (47%) had rash and/or mucositis, including erythema, morbilliform, retiform purpura, targetoid and urticarial patterns, along with acral edema, lip mucositis, tongue papillitis, and conjunctivitis. COVID-19 patients with rash had less frequent respiratory symptoms, pediatric intensive care unit admission, invasive ventilation, and shorter stay versus COVID-19 patients without rash. MIS-C patients with rash had less frequent pediatric intensive care unit admission, shock, ventilation, as well as lower levels of C-reactive protein, ferritin, D-dimer, and troponin (vs MIS-C without rash). Neutrophil-to-lymphocyte ratio was similar for patients with and without rash in both groups. None of the MIS-C patients met criteria for Kawasaki disease. LIMITATIONS: Small sample sizes. CONCLUSIONS: Mucocutaneous disease is common among children and adolescents with COVID-19 and MIS-C. Laboratory trends observed in patients with rash may prognosticate a less severe course. |
format | Online Article Text |
id | pubmed-7585496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | by the American Academy of Dermatology, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75854962020-10-26 Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children Rekhtman, Sergey Tannenbaum, Rachel Strunk, Andrew Birabaharan, Morgan Wright, Shari Garg, Amit J Am Acad Dermatol Original Article BACKGROUND: Little is known about mucocutaneous disease in acutely ill children and adolescents with COVID-19 and multisystem inflammatory syndrome in children (MIS-C). OBJECTIVE: To characterize mucocutaneous disease and its relation to clinical course among hospitalized patients with COVID-19 and MIS-C. METHODS: Descriptive cohort study of prospectively and consecutively hospitalized eligible patients between May 11, 2020 and June 5, 2020. RESULTS: In COVID-19 patients, 4 of 12 (33%) had rash and/or mucositis, including erythema, morbilliform pattern, and lip mucositis. In MIS-C patients, 9 of 19 (47%) had rash and/or mucositis, including erythema, morbilliform, retiform purpura, targetoid and urticarial patterns, along with acral edema, lip mucositis, tongue papillitis, and conjunctivitis. COVID-19 patients with rash had less frequent respiratory symptoms, pediatric intensive care unit admission, invasive ventilation, and shorter stay versus COVID-19 patients without rash. MIS-C patients with rash had less frequent pediatric intensive care unit admission, shock, ventilation, as well as lower levels of C-reactive protein, ferritin, D-dimer, and troponin (vs MIS-C without rash). Neutrophil-to-lymphocyte ratio was similar for patients with and without rash in both groups. None of the MIS-C patients met criteria for Kawasaki disease. LIMITATIONS: Small sample sizes. CONCLUSIONS: Mucocutaneous disease is common among children and adolescents with COVID-19 and MIS-C. Laboratory trends observed in patients with rash may prognosticate a less severe course. by the American Academy of Dermatology, Inc. 2021-02 2020-10-24 /pmc/articles/PMC7585496/ /pubmed/33323343 http://dx.doi.org/10.1016/j.jaad.2020.10.060 Text en © 2020 by the American Academy of Dermatology, Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Rekhtman, Sergey Tannenbaum, Rachel Strunk, Andrew Birabaharan, Morgan Wright, Shari Garg, Amit Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title | Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title_full | Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title_fullStr | Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title_full_unstemmed | Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title_short | Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children |
title_sort | mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with covid-19 and multisystem inflammatory syndrome in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585496/ https://www.ncbi.nlm.nih.gov/pubmed/33323343 http://dx.doi.org/10.1016/j.jaad.2020.10.060 |
work_keys_str_mv | AT rekhtmansergey mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren AT tannenbaumrachel mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren AT strunkandrew mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren AT birabaharanmorgan mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren AT wrightshari mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren AT gargamit mucocutaneousdiseaseandrelatedclinicalcharacteristicsinhospitalizedchildrenandadolescentswithcovid19andmultisysteminflammatorysyndromeinchildren |