Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium damage, somatic electromotility disturbances, and presynaptic ribbon degeneration over time, which led to the gradu...

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Detalles Bibliográficos
Autores principales: Zhou, Han, Qian, Xiaoyun, Xu, Nana, Zhang, Shasha, Zhu, Guangjie, Zhang, Yuan, Liu, Dingding, Cheng, Cheng, Zhu, Xiaocheng, Liu, Yongze, Lu, Ling, Tang, Jie, Chai, Renjie, Gao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585579/
https://www.ncbi.nlm.nih.gov/pubmed/33099575
http://dx.doi.org/10.1038/s41419-020-03110-8

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