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Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study

Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD. Study design: A case-control study. Methods: In...

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Autores principales: Salehi-Sahlabadi, Ammar, Mokari, Amin, Elhamkia, Maryam, Farahmand, Fariba, Jabbari, Masoumeh, Hekmatdoost, Azita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hamadan University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585767/
https://www.ncbi.nlm.nih.gov/pubmed/33169718
http://dx.doi.org/10.34172/jrhs.2020.18
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author Salehi-Sahlabadi, Ammar
Mokari, Amin
Elhamkia, Maryam
Farahmand, Fariba
Jabbari, Masoumeh
Hekmatdoost, Azita
author_facet Salehi-Sahlabadi, Ammar
Mokari, Amin
Elhamkia, Maryam
Farahmand, Fariba
Jabbari, Masoumeh
Hekmatdoost, Azita
author_sort Salehi-Sahlabadi, Ammar
collection PubMed
description Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD. Study design: A case-control study. Methods: In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐ item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC. Results: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P <0.050), and lower physical activity and DTAC scores (P <0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91). Conclusion: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.
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spelling pubmed-75857672020-10-27 Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study Salehi-Sahlabadi, Ammar Mokari, Amin Elhamkia, Maryam Farahmand, Fariba Jabbari, Masoumeh Hekmatdoost, Azita J Res Health Sci Original Article Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD. Study design: A case-control study. Methods: In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐ item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC. Results: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P <0.050), and lower physical activity and DTAC scores (P <0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91). Conclusion: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results. Hamadan University of Medical Sciences 2020-07-30 /pmc/articles/PMC7585767/ /pubmed/33169718 http://dx.doi.org/10.34172/jrhs.2020.18 Text en © 2020 The Author(s); Published by Hamadan University of Medical Sciences. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Salehi-Sahlabadi, Ammar
Mokari, Amin
Elhamkia, Maryam
Farahmand, Fariba
Jabbari, Masoumeh
Hekmatdoost, Azita
Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title_full Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title_fullStr Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title_full_unstemmed Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title_short Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study
title_sort dietary total antioxidant capacity and risk of non-alcoholic fatty liver disease: a case‐control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585767/
https://www.ncbi.nlm.nih.gov/pubmed/33169718
http://dx.doi.org/10.34172/jrhs.2020.18
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