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Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment

BACKGROUND: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing do...

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Detalles Bibliográficos
Autores principales: Shrestha, Binita, Wang, Lijun, Zhang, Hao, Hung, Chiung Yu, Tang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585780/
https://www.ncbi.nlm.nih.gov/pubmed/33116521
http://dx.doi.org/10.2147/IJN.S258625
Descripción
Sumario:BACKGROUND: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects. METHODS: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co-delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release. RESULTS: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC(50) value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model. CONCLUSION: This study may provide an adaptable, facile platform to investigate drug-siRNA combinations for cancer inhibition.