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Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System

Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticl...

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Autores principales: Wathoni, Nasrul, Nguyen, An Ny, Rusdin, Agus, Umar, Abd Kakhar, Mohammed, Ahmed Fouad Abdelwahab, Motoyama, Keiichi, Joni, I Made, Muchtaridi, Muchtaridi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585804/
https://www.ncbi.nlm.nih.gov/pubmed/33116423
http://dx.doi.org/10.2147/DDDT.S273612
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author Wathoni, Nasrul
Nguyen, An Ny
Rusdin, Agus
Umar, Abd Kakhar
Mohammed, Ahmed Fouad Abdelwahab
Motoyama, Keiichi
Joni, I Made
Muchtaridi, Muchtaridi
author_facet Wathoni, Nasrul
Nguyen, An Ny
Rusdin, Agus
Umar, Abd Kakhar
Mohammed, Ahmed Fouad Abdelwahab
Motoyama, Keiichi
Joni, I Made
Muchtaridi, Muchtaridi
author_sort Wathoni, Nasrul
collection PubMed
description Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration.
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spelling pubmed-75858042020-10-27 Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System Wathoni, Nasrul Nguyen, An Ny Rusdin, Agus Umar, Abd Kakhar Mohammed, Ahmed Fouad Abdelwahab Motoyama, Keiichi Joni, I Made Muchtaridi, Muchtaridi Drug Des Devel Ther Review Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration. Dove 2020-10-21 /pmc/articles/PMC7585804/ /pubmed/33116423 http://dx.doi.org/10.2147/DDDT.S273612 Text en © 2020 Wathoni et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wathoni, Nasrul
Nguyen, An Ny
Rusdin, Agus
Umar, Abd Kakhar
Mohammed, Ahmed Fouad Abdelwahab
Motoyama, Keiichi
Joni, I Made
Muchtaridi, Muchtaridi
Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title_full Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title_fullStr Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title_full_unstemmed Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title_short Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
title_sort enteric-coated strategies in colorectal cancer nanoparticle drug delivery system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585804/
https://www.ncbi.nlm.nih.gov/pubmed/33116423
http://dx.doi.org/10.2147/DDDT.S273612
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