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Epigenetic mechanisms in Tendon Ageing
INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585832/ https://www.ncbi.nlm.nih.gov/pubmed/32827252 http://dx.doi.org/10.1093/bmb/ldaa023 |
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author | Riasat, Kiran Bardell, David Goljanek-Whysall, Katarzyna Clegg, Peter D Peffers, Mandy J |
author_facet | Riasat, Kiran Bardell, David Goljanek-Whysall, Katarzyna Clegg, Peter D Peffers, Mandy J |
author_sort | Riasat, Kiran |
collection | PubMed |
description | INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. SOURCES OF DATA: We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. AREAS OF AGREEMENT: Epigenetic mechanisms are important in predisposing ageing tendon to injury. AREAS OF CONTROVERSY: The relative importance of epigenetic mechanisms are unknown in terms of promoting healthy ageing. It is also unknown whether these changes represent protective mechanisms to function or predispose to pathology. GROWING POINT: Epigenetic markers in ageing tendon, which are under-researched including genome-wide chromatin accessibility, should be investigated. AREAS TIMELY FOR DEVELOPING RESEARCH: Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease. |
format | Online Article Text |
id | pubmed-7585832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75858322020-10-30 Epigenetic mechanisms in Tendon Ageing Riasat, Kiran Bardell, David Goljanek-Whysall, Katarzyna Clegg, Peter D Peffers, Mandy J Br Med Bull Invited Review INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. SOURCES OF DATA: We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. AREAS OF AGREEMENT: Epigenetic mechanisms are important in predisposing ageing tendon to injury. AREAS OF CONTROVERSY: The relative importance of epigenetic mechanisms are unknown in terms of promoting healthy ageing. It is also unknown whether these changes represent protective mechanisms to function or predispose to pathology. GROWING POINT: Epigenetic markers in ageing tendon, which are under-researched including genome-wide chromatin accessibility, should be investigated. AREAS TIMELY FOR DEVELOPING RESEARCH: Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease. Oxford University Press 2020-08-22 /pmc/articles/PMC7585832/ /pubmed/32827252 http://dx.doi.org/10.1093/bmb/ldaa023 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Riasat, Kiran Bardell, David Goljanek-Whysall, Katarzyna Clegg, Peter D Peffers, Mandy J Epigenetic mechanisms in Tendon Ageing |
title | Epigenetic mechanisms in Tendon Ageing |
title_full | Epigenetic mechanisms in Tendon Ageing |
title_fullStr | Epigenetic mechanisms in Tendon Ageing |
title_full_unstemmed | Epigenetic mechanisms in Tendon Ageing |
title_short | Epigenetic mechanisms in Tendon Ageing |
title_sort | epigenetic mechanisms in tendon ageing |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585832/ https://www.ncbi.nlm.nih.gov/pubmed/32827252 http://dx.doi.org/10.1093/bmb/ldaa023 |
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