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Epigenetic mechanisms in Tendon Ageing

INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes...

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Autores principales: Riasat, Kiran, Bardell, David, Goljanek-Whysall, Katarzyna, Clegg, Peter D, Peffers, Mandy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585832/
https://www.ncbi.nlm.nih.gov/pubmed/32827252
http://dx.doi.org/10.1093/bmb/ldaa023
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author Riasat, Kiran
Bardell, David
Goljanek-Whysall, Katarzyna
Clegg, Peter D
Peffers, Mandy J
author_facet Riasat, Kiran
Bardell, David
Goljanek-Whysall, Katarzyna
Clegg, Peter D
Peffers, Mandy J
author_sort Riasat, Kiran
collection PubMed
description INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. SOURCES OF DATA: We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. AREAS OF AGREEMENT: Epigenetic mechanisms are important in predisposing ageing tendon to injury. AREAS OF CONTROVERSY: The relative importance of epigenetic mechanisms are unknown in terms of promoting healthy ageing. It is also unknown whether these changes represent protective mechanisms to function or predispose to pathology. GROWING POINT: Epigenetic markers in ageing tendon, which are under-researched including genome-wide chromatin accessibility, should be investigated. AREAS TIMELY FOR DEVELOPING RESEARCH: Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease.
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spelling pubmed-75858322020-10-30 Epigenetic mechanisms in Tendon Ageing Riasat, Kiran Bardell, David Goljanek-Whysall, Katarzyna Clegg, Peter D Peffers, Mandy J Br Med Bull Invited Review INTRODUCTION: Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. SOURCES OF DATA: We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. AREAS OF AGREEMENT: Epigenetic mechanisms are important in predisposing ageing tendon to injury. AREAS OF CONTROVERSY: The relative importance of epigenetic mechanisms are unknown in terms of promoting healthy ageing. It is also unknown whether these changes represent protective mechanisms to function or predispose to pathology. GROWING POINT: Epigenetic markers in ageing tendon, which are under-researched including genome-wide chromatin accessibility, should be investigated. AREAS TIMELY FOR DEVELOPING RESEARCH: Metanalysis through integration of multiple datasets and platforms will enable a holistic understanding of the epigenome in ageing and its relevance to disease. Oxford University Press 2020-08-22 /pmc/articles/PMC7585832/ /pubmed/32827252 http://dx.doi.org/10.1093/bmb/ldaa023 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Riasat, Kiran
Bardell, David
Goljanek-Whysall, Katarzyna
Clegg, Peter D
Peffers, Mandy J
Epigenetic mechanisms in Tendon Ageing
title Epigenetic mechanisms in Tendon Ageing
title_full Epigenetic mechanisms in Tendon Ageing
title_fullStr Epigenetic mechanisms in Tendon Ageing
title_full_unstemmed Epigenetic mechanisms in Tendon Ageing
title_short Epigenetic mechanisms in Tendon Ageing
title_sort epigenetic mechanisms in tendon ageing
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585832/
https://www.ncbi.nlm.nih.gov/pubmed/32827252
http://dx.doi.org/10.1093/bmb/ldaa023
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