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Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study

BACKGROUND: Unfavorable sleep habits have been linked with ischemic stroke in observational studies, but the causality remains unclear. The aim of this study is to investigate the potential causal role of three sleep traits, including sleep duration, insomnia, and chronotype, in ischemic stroke and...

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Autores principales: Cai, Huan, Liang, Jialin, Liu, Zhonghua, Fang, Liang, Zheng, Jinghong, Xu, Jiahe, Chen, Liyi, Sun, Wen, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585859/
https://www.ncbi.nlm.nih.gov/pubmed/33117014
http://dx.doi.org/10.2147/NSS.S265946
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author Cai, Huan
Liang, Jialin
Liu, Zhonghua
Fang, Liang
Zheng, Jinghong
Xu, Jiahe
Chen, Liyi
Sun, Wen
Zhang, Hao
author_facet Cai, Huan
Liang, Jialin
Liu, Zhonghua
Fang, Liang
Zheng, Jinghong
Xu, Jiahe
Chen, Liyi
Sun, Wen
Zhang, Hao
author_sort Cai, Huan
collection PubMed
description BACKGROUND: Unfavorable sleep habits have been linked with ischemic stroke in observational studies, but the causality remains unclear. The aim of this study is to investigate the potential causal role of three sleep traits, including sleep duration, insomnia, and chronotype, in ischemic stroke and its subtypes. METHODS: We conducted two-sample Mendelian randomization (MR) analysis using single nucleotide polymorphisms associated with sleep duration, insomnia, and chronotype as instruments to estimate causal associations with ischemic stroke and its subtypes, among 34,217 ischemic stroke cases and 406,111 controls from the MEGASTROKE consortium. Inverse-variance weighted method was used as the main analyses. Alternative MR methods and sensitivity analyses were further performed. RESULTS: We found suggestive evidence that per doubling of genetic liability for short sleep duration (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.01–1.58) and frequent insomnia symptoms (OR, 1.19; 95% CI, 1.00–1.41) were associated with a modest increase in risk of large artery stroke (LAS) but not with small vessel stroke, cardioembolic stroke, or any ischemic stroke. The association of frequent insomnia symptoms with LAS was stronger after the exclusion of the outlier (OR, 1.25; 95% CI, 1.04–1.50). No significant association was observed for chronotype with any ischemic stroke subtype. Results were overall robust to sensitivity analyses, and there was little evidence of horizontal pleiotropy. CONCLUSION: We provided suggestive evidence for a potential causal role of short sleep duration and insomnia symptoms in LAS. Future researches are required to investigate whether improved sleep habits could help to mitigate LAS risk.
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spelling pubmed-75858592020-10-27 Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study Cai, Huan Liang, Jialin Liu, Zhonghua Fang, Liang Zheng, Jinghong Xu, Jiahe Chen, Liyi Sun, Wen Zhang, Hao Nat Sci Sleep Original Research BACKGROUND: Unfavorable sleep habits have been linked with ischemic stroke in observational studies, but the causality remains unclear. The aim of this study is to investigate the potential causal role of three sleep traits, including sleep duration, insomnia, and chronotype, in ischemic stroke and its subtypes. METHODS: We conducted two-sample Mendelian randomization (MR) analysis using single nucleotide polymorphisms associated with sleep duration, insomnia, and chronotype as instruments to estimate causal associations with ischemic stroke and its subtypes, among 34,217 ischemic stroke cases and 406,111 controls from the MEGASTROKE consortium. Inverse-variance weighted method was used as the main analyses. Alternative MR methods and sensitivity analyses were further performed. RESULTS: We found suggestive evidence that per doubling of genetic liability for short sleep duration (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.01–1.58) and frequent insomnia symptoms (OR, 1.19; 95% CI, 1.00–1.41) were associated with a modest increase in risk of large artery stroke (LAS) but not with small vessel stroke, cardioembolic stroke, or any ischemic stroke. The association of frequent insomnia symptoms with LAS was stronger after the exclusion of the outlier (OR, 1.25; 95% CI, 1.04–1.50). No significant association was observed for chronotype with any ischemic stroke subtype. Results were overall robust to sensitivity analyses, and there was little evidence of horizontal pleiotropy. CONCLUSION: We provided suggestive evidence for a potential causal role of short sleep duration and insomnia symptoms in LAS. Future researches are required to investigate whether improved sleep habits could help to mitigate LAS risk. Dove 2020-10-21 /pmc/articles/PMC7585859/ /pubmed/33117014 http://dx.doi.org/10.2147/NSS.S265946 Text en © 2020 Cai et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Cai, Huan
Liang, Jialin
Liu, Zhonghua
Fang, Liang
Zheng, Jinghong
Xu, Jiahe
Chen, Liyi
Sun, Wen
Zhang, Hao
Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title_full Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title_fullStr Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title_full_unstemmed Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title_short Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
title_sort causal effects of sleep traits on ischemic stroke and its subtypes: a mendelian randomization study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585859/
https://www.ncbi.nlm.nih.gov/pubmed/33117014
http://dx.doi.org/10.2147/NSS.S265946
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