Cargando…
Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis
Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585905/ https://www.ncbi.nlm.nih.gov/pubmed/33086877 http://dx.doi.org/10.1177/2515690X20967323 |
_version_ | 1783599889867866112 |
---|---|
author | Shinjyo, Noriko Waddell, Guy Green, Julia |
author_facet | Shinjyo, Noriko Waddell, Guy Green, Julia |
author_sort | Shinjyo, Noriko |
collection | PubMed |
description | Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders. PubMed, ScienceDirect, and Cochrane Library were searched to retrieve publications relevant to the effectiveness of valerian as a treatment of sleep problems and associated disorders. A total of 60 studies (n=6,894) were included in this review, and meta-analyses were performed to evaluate the effectiveness to improve subjective sleep quality (10 studies, n=1,065) and to reduce anxiety (8 studies, n=535). Results suggested that inconsistent outcomes were possibly due to the variable quality of herbal extracts and that more reliable effects could be expected from the whole root/rhizome. In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners. There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years. In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders. However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life. |
format | Online Article Text |
id | pubmed-7585905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75859052020-11-03 Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis Shinjyo, Noriko Waddell, Guy Green, Julia J Evid Based Integr Med Topical Review Article Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders. PubMed, ScienceDirect, and Cochrane Library were searched to retrieve publications relevant to the effectiveness of valerian as a treatment of sleep problems and associated disorders. A total of 60 studies (n=6,894) were included in this review, and meta-analyses were performed to evaluate the effectiveness to improve subjective sleep quality (10 studies, n=1,065) and to reduce anxiety (8 studies, n=535). Results suggested that inconsistent outcomes were possibly due to the variable quality of herbal extracts and that more reliable effects could be expected from the whole root/rhizome. In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners. There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years. In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders. However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life. SAGE Publications 2020-10-21 /pmc/articles/PMC7585905/ /pubmed/33086877 http://dx.doi.org/10.1177/2515690X20967323 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Topical Review Article Shinjyo, Noriko Waddell, Guy Green, Julia Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title | Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title_full | Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title_fullStr | Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title_full_unstemmed | Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title_short | Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis |
title_sort | valerian root in treating sleep problems and associated disorders—a systematic review and meta-analysis |
topic | Topical Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585905/ https://www.ncbi.nlm.nih.gov/pubmed/33086877 http://dx.doi.org/10.1177/2515690X20967323 |
work_keys_str_mv | AT shinjyonoriko valerianrootintreatingsleepproblemsandassociateddisordersasystematicreviewandmetaanalysis AT waddellguy valerianrootintreatingsleepproblemsandassociateddisordersasystematicreviewandmetaanalysis AT greenjulia valerianrootintreatingsleepproblemsandassociateddisordersasystematicreviewandmetaanalysis |