Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model

Friedreich ataxia (FRDA) is a neurodegenerative disorder characterized by neuromuscular and neurological manifestations. It is caused by mutations in the FXN gene, which results in loss of the mitochondrial protein frataxin. Endoplasmic Reticulum-mitochondria associated membranes (MAMs) are inter-or...

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Detalles Bibliográficos
Autores principales: Rodríguez, Laura R., Calap-Quintana, Pablo, Lapeña-Luzón, Tamara, Pallardó, Federico V., Schneuwly, Stephan, Navarro, Juan A., Gonzalez-Cabo, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585950/
https://www.ncbi.nlm.nih.gov/pubmed/33128998
http://dx.doi.org/10.1016/j.redox.2020.101762

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