Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma

Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer st...

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Autores principales: Lu, Yu-bao, Sun, Tian-Jiao, Chen, Yu-tong, Cai, Zong-Yan, Zhao, Jia-Yu, Miao, Feng, Yang, Yong-na, Wang, Shi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586027/
https://www.ncbi.nlm.nih.gov/pubmed/33089751
http://dx.doi.org/10.1177/1533033820948053
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author Lu, Yu-bao
Sun, Tian-Jiao
Chen, Yu-tong
Cai, Zong-Yan
Zhao, Jia-Yu
Miao, Feng
Yang, Yong-na
Wang, Shi-Xin
author_facet Lu, Yu-bao
Sun, Tian-Jiao
Chen, Yu-tong
Cai, Zong-Yan
Zhao, Jia-Yu
Miao, Feng
Yang, Yong-na
Wang, Shi-Xin
author_sort Lu, Yu-bao
collection PubMed
description Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
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spelling pubmed-75860272020-11-03 Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma Lu, Yu-bao Sun, Tian-Jiao Chen, Yu-tong Cai, Zong-Yan Zhao, Jia-Yu Miao, Feng Yang, Yong-na Wang, Shi-Xin Technol Cancer Res Treat Review Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma. SAGE Publications 2020-10-22 /pmc/articles/PMC7586027/ /pubmed/33089751 http://dx.doi.org/10.1177/1533033820948053 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Lu, Yu-bao
Sun, Tian-Jiao
Chen, Yu-tong
Cai, Zong-Yan
Zhao, Jia-Yu
Miao, Feng
Yang, Yong-na
Wang, Shi-Xin
Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_full Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_fullStr Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_full_unstemmed Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_short Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
title_sort targeting the epithelial-to-mesenchymal transition in cancer stem cells for a better clinical outcome of glioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586027/
https://www.ncbi.nlm.nih.gov/pubmed/33089751
http://dx.doi.org/10.1177/1533033820948053
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