Cargando…

Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway

N-methyl-N´-nitro-N-nitrosoguanidine is a clear carcinogen, increasing evidence that indicates an etiological role of human papillomavirus in esophageal carcinoma. Studies have reported the synergistic effect on environmental carcinogens and viruses in recent years. On the basis of establishing the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ying, Ma, Yue, Zhao, Chao, Zhang, Hu, Pu, Yuepu, Yin, Lihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586040/ https://www.ncbi.nlm.nih.gov/pubmed/33123313 http://dx.doi.org/10.1155/2020/6352876

Ejemplares similares

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
por: Kageyama, Shun, et al.
Publicado: (2018)

Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway
por: Zhu, Feiye, et al.
Publicado: (2021)

MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling
por: Tan, Chong Teik, et al.
Publicado: (2021)

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage
por: Tan, Xin, et al.
Publicado: (2020)

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells
por: Tsai, Te-Fu, et al.
Publicado: (2020)

Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Pathway
por: Guo, Yingying, et al.
Publicado: (2022)

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways
por: Seo, Hye-Young, et al.
Publicado: (2020)

p62 promotes bladder cancer cell growth by activating KEAP1/NRF2‐dependent antioxidative response
por: Li, Tao, et al.
Publicado: (2020)

Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway
por: Gao, Ping, et al.
Publicado: (2021)

Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway
por: Tang, Kezhong, et al.
Publicado: (2022)

Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury
por: Li, Xuan, et al.
Publicado: (2022)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Arbres PS/HET et SE62 Starting-up
por: Steinbach, C
Publicado: (1982)

PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway
por: Lee, Da Hyun, et al.
Publicado: (2022)

Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway
por: Gong, Wan, et al.
Publicado: (2022)

Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats
por: Rehman, Muneeb U., et al.
Publicado: (2020)

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop
por: Wang, Yang, et al.
Publicado: (2017)

p62 promotes proliferation, apoptosis-resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis
por: Jiang, Ganggang, et al.
Publicado: (2020)

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage
por: Deng, Shan, et al.
Publicado: (2020)

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice
por: Jia, Yuxin, et al.
Publicado: (2021)

LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway
por: Wang, TingAn, et al.
Publicado: (2022)

Dendrobium Officinale Polysaccharides Protect against MNNG-Induced PLGC in Rats via Activating the NRF2 and Antioxidant Enzymes HO-1 and NQO-1
por: Zhao, Yi, et al.
Publicado: (2019)

Cellular response to alkylating agent MNNG is impaired in STAT1‐deficients cells
por: Ah‐Koon, Laurent, et al.
Publicado: (2016)

Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
por: Hsu, Wei-Lun, et al.
Publicado: (2022)

Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1
por: Yang, Miao, et al.
Publicado: (2015)

PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications
por: Aguayo, Francisco, et al.
Publicado: (2023)

Structural basis of Keap1 interactions with Nrf2
por: Canning, Peter, et al.
Publicado: (2015)

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
por: Bhattacharjee, Shamee, et al.
Publicado: (2020)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

The KEAP1-NRF2 System and Esophageal Cancer
por: Hirose, Wataru, et al.
Publicado: (2022)

Modulation of NRF2/KEAP1 Signaling in Preeclampsia
por: Tossetta, Giovanni, et al.
Publicado: (2023)

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway
por: Wang, Fang, et al.
Publicado: (2021)

Protective Effect of Geraniol on Oxidative, Inflammatory and Apoptotic Alterations in Isoproterenol-Induced Cardiotoxicity: Role of the Keap1/Nrf2/HO-1 and PI3K/Akt/mTOR Pathways
por: Younis, Nancy S., et al.
Publicado: (2020)

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010)

p62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex
por: Garufi, Alessia, et al.
Publicado: (2021)

Anti-Inflammatory and Antioxidant Effects of Carvacrol on N-Methyl-N′-Nitro-N-Nitrosoguanidine (MNNG) Induced Gastric Carcinogenesis in Wistar Rats
por: Gunes-Bayir, Ayse, et al.
Publicado: (2022)

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop
por: Fan, Menglin, et al.
Publicado: (2018)

The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity
por: Lee, Da Hyun, et al.
Publicado: (2017)

p62 Suppressed VK3-induced Oxidative Damage Through Keap1/Nrf2 Pathway In Human Ovarian Cancer Cells
por: Xia, Mei-hui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_58hil26896otkcrflb82f8fv5e