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Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()

The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cell...

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Detalles Bibliográficos
Autores principales: Taurin, Sebastien, Alkhalifa, Haifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/
https://www.ncbi.nlm.nih.gov/pubmed/33142233
http://dx.doi.org/10.1016/j.neo.2020.09.009
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author Taurin, Sebastien
Alkhalifa, Haifa
author_facet Taurin, Sebastien
Alkhalifa, Haifa
author_sort Taurin, Sebastien
collection PubMed
description The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations.
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spelling pubmed-75860612020-10-30 Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() Taurin, Sebastien Alkhalifa, Haifa Neoplasia Review article The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations. Neoplasia Press 2020-10-23 /pmc/articles/PMC7586061/ /pubmed/33142233 http://dx.doi.org/10.1016/j.neo.2020.09.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review article
Taurin, Sebastien
Alkhalifa, Haifa
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title_full Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title_fullStr Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title_full_unstemmed Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title_short Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
title_sort breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/
https://www.ncbi.nlm.nih.gov/pubmed/33142233
http://dx.doi.org/10.1016/j.neo.2020.09.009
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