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Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()()
The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cell...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/ https://www.ncbi.nlm.nih.gov/pubmed/33142233 http://dx.doi.org/10.1016/j.neo.2020.09.009 |
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author | Taurin, Sebastien Alkhalifa, Haifa |
author_facet | Taurin, Sebastien Alkhalifa, Haifa |
author_sort | Taurin, Sebastien |
collection | PubMed |
description | The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations. |
format | Online Article Text |
id | pubmed-7586061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75860612020-10-30 Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() Taurin, Sebastien Alkhalifa, Haifa Neoplasia Review article The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations. Neoplasia Press 2020-10-23 /pmc/articles/PMC7586061/ /pubmed/33142233 http://dx.doi.org/10.1016/j.neo.2020.09.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Taurin, Sebastien Alkhalifa, Haifa Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title_full | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title_fullStr | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title_full_unstemmed | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title_short | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
title_sort | breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses()() |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/ https://www.ncbi.nlm.nih.gov/pubmed/33142233 http://dx.doi.org/10.1016/j.neo.2020.09.009 |
work_keys_str_mv | AT taurinsebastien breastcancersmammarystemcellsandcancerstemcellscharacteristicsandhypotheses AT alkhalifahaifa breastcancersmammarystemcellsandcancerstemcellscharacteristicsandhypotheses |