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Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37–Viruses That Cause Highly Contagious Eye Infections
[Image: see text] Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively. Currently, neither vaccines nor antiviral agent...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586296/ https://www.ncbi.nlm.nih.gov/pubmed/32845119 http://dx.doi.org/10.1021/acschembio.0c00446 |
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author | Johansson, Emil Caraballo, Rémi Mistry, Nitesh Zocher, Georg Qian, Weixing Andersson, C. David Hurdiss, Daniel L. Chandra, Naresh Thompson, Rebecca Frängsmyr, Lars Stehle, Thilo Arnberg, Niklas Elofsson, Mikael |
author_facet | Johansson, Emil Caraballo, Rémi Mistry, Nitesh Zocher, Georg Qian, Weixing Andersson, C. David Hurdiss, Daniel L. Chandra, Naresh Thompson, Rebecca Frängsmyr, Lars Stehle, Thilo Arnberg, Niklas Elofsson, Mikael |
author_sort | Johansson, Emil |
collection | PubMed |
description | [Image: see text] Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively. Currently, neither vaccines nor antiviral agents are available for treating these diseases, which affect millions of individuals worldwide. CVA24v and HAdV-37 utilize sialic acid as attachment receptors facilitating entry into host cells. Previously, we and others have shown that derivatives based on sialic acid are effective in preventing HAdV-37 binding and infection of cells. Here, we designed and synthesized novel pentavalent sialic acid conjugates and studied their inhibitory effect against CVA24v and HAdV-37 binding and infection of human corneal epithelial cells. The pentavalent conjugates are the first reported inhibitors of CVA24v infection and proved efficient in blocking HAdV-37 binding. Taken together, the pentavalent conjugates presented here form a basis for the development of general inhibitors of these highly contagious ocular pathogens. |
format | Online Article Text |
id | pubmed-7586296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-75862962020-10-27 Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37–Viruses That Cause Highly Contagious Eye Infections Johansson, Emil Caraballo, Rémi Mistry, Nitesh Zocher, Georg Qian, Weixing Andersson, C. David Hurdiss, Daniel L. Chandra, Naresh Thompson, Rebecca Frängsmyr, Lars Stehle, Thilo Arnberg, Niklas Elofsson, Mikael ACS Chem Biol [Image: see text] Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively. Currently, neither vaccines nor antiviral agents are available for treating these diseases, which affect millions of individuals worldwide. CVA24v and HAdV-37 utilize sialic acid as attachment receptors facilitating entry into host cells. Previously, we and others have shown that derivatives based on sialic acid are effective in preventing HAdV-37 binding and infection of cells. Here, we designed and synthesized novel pentavalent sialic acid conjugates and studied their inhibitory effect against CVA24v and HAdV-37 binding and infection of human corneal epithelial cells. The pentavalent conjugates are the first reported inhibitors of CVA24v infection and proved efficient in blocking HAdV-37 binding. Taken together, the pentavalent conjugates presented here form a basis for the development of general inhibitors of these highly contagious ocular pathogens. American Chemical Society 2020-08-26 2020-10-16 /pmc/articles/PMC7586296/ /pubmed/32845119 http://dx.doi.org/10.1021/acschembio.0c00446 Text en This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
spellingShingle | Johansson, Emil Caraballo, Rémi Mistry, Nitesh Zocher, Georg Qian, Weixing Andersson, C. David Hurdiss, Daniel L. Chandra, Naresh Thompson, Rebecca Frängsmyr, Lars Stehle, Thilo Arnberg, Niklas Elofsson, Mikael Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37–Viruses That Cause Highly Contagious Eye Infections |
title | Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections |
title_full | Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections |
title_fullStr | Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections |
title_full_unstemmed | Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections |
title_short | Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections |
title_sort | pentavalent sialic acid conjugates block coxsackievirus
a24 variant and human adenovirus type 37–viruses that cause
highly contagious eye infections |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586296/ https://www.ncbi.nlm.nih.gov/pubmed/32845119 http://dx.doi.org/10.1021/acschembio.0c00446 |
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