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C(60) in a peptidic cage: a case of symmetry mismatch studied by crystallography and solid-state NMR

A supramolecular complex, formed by encapsulation of C(60) fullerene in a molecular container built from two resorcin[4]arene rims zipped together by peptidic arms hydrogen bonded into a cylindrical β-sheet, was studied by X-ray crystallography, solid-state and solution NMR, EPR spectroscopy and dif...

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Detalles Bibliográficos
Autores principales: Gilski, Miroslaw, Bernatowicz, Piotr, Sakowicz, Arkadiusz, Szymański, Marek P., Zalewska, Aldona, Szumna, Agnieszka, Jaskólski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586347/
https://www.ncbi.nlm.nih.gov/pubmed/33017315
http://dx.doi.org/10.1107/S2052520620009944
Descripción
Sumario:A supramolecular complex, formed by encapsulation of C(60) fullerene in a molecular container built from two resorcin[4]arene rims zipped together by peptidic arms hydrogen bonded into a cylindrical β-sheet, was studied by X-ray crystallography, solid-state and solution NMR, EPR spectroscopy and differential scanning calorimetry (DSC). The crystal structure, determined at 100 K, reveals that the complex occupies 422 site symmetry, which is compatible with the molecular symmetry of the container but not of the fullerene molecule, which has only 222 symmetry. The additional crystallographic symmetry leads to a complicated but discrete dis­order, which could be resolved and modelled using advanced features of the existing refinement software. Solid-state NMR measurements at 184–333 K indicate that the thermal motion of C(60) in this temperature range is fast but has different activation energies at different temperatures, which was attributed to a phase transition, which was confirmed by DSC. Intriguingly, the activation energy for reorientations of C(60) in the solid state is very similar for the free and encaged molecules. Also, the rotational diffusion coefficients seem to be very similar or even slightly higher for the encaged fullerene compared to the free molecule. We also found that chemical shift anisotropy (CSA) is not the main relaxation mechanism for the (13)C spins of C(60) in the studied complex.