Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket

[Image: see text] Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that regulate fundamental processes, such as organogenesis and cell growth, and elevated TEAD activity is associated with tumorigenesi...

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Detalles Bibliográficos
Autores principales: Karatas, Hacer, Akbarzadeh, Mohammad, Adihou, Hélène, Hahne, Gernot, Pobbati, Ajaybabu V., Yihui Ng, Elizabeth, Guéret, Stéphanie M., Sievers, Sonja, Pahl, Axel, Metz, Malte, Zinken, Sarah, Dötsch, Lara, Nowak, Christine, Thavam, Sasikala, Friese, Alexandra, Kang, CongBao, Hong, Wanjin, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586386/
https://www.ncbi.nlm.nih.gov/pubmed/32907324
http://dx.doi.org/10.1021/acs.jmedchem.0c01275

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