Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling

BACKGROUND: We previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency (CIRCI) and mortality in rats with traumatic brain injury (TBI), whereas low-dose hydrocortisone but not methylprednisolone exerted protective effects. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Bin, Bai, Miao, Xu, Xiaojian, Yang, Mengshi, Niu, Fei, Gao, Fei, Liu, Baiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586672/
https://www.ncbi.nlm.nih.gov/pubmed/33100225
http://dx.doi.org/10.1186/s12974-020-02000-2

Ejemplares similares

Ejemplares similares