Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

BACKGROUND: Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determining region Y-box 2 (SOX2) overlapping transcript (SOX2OT), a known regulator of...

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Detalles Bibliográficos
Autores principales: Yin, Jialin, Shen, Yanan, Si, Yanna, Zhang, Yuan, Du, Jiayue, Hu, Xiajuan, Cai, Mengmeng, Bao, Hongguang, Xing, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586681/
https://www.ncbi.nlm.nih.gov/pubmed/33100215
http://dx.doi.org/10.1186/s12974-020-01970-7

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