Cargando…

Phase 1 Study to Evaluate the Effect of the Investigational Anticancer Agent Sapanisertib on the QTc Interval in Patients With Advanced Solid Tumors

The aim of this phase 1 study was to determine the effects of sapanisertib on the heart rate–corrected QT (QTc) interval in patients with advanced solid tumors. Adult patients with advanced solid tumors were enrolled to receive a single sapanisertib 40‐mg dose. Blood samples for pharmacokinetic anal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Chirag, Goel, Sanjay, Patel, Manish R., Rangachari, Lakshmi, Wilbur, Jayson D., Shou, Yaping, Venkatakrishnan, Karthik, Lockhart, A. Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586797/ https://www.ncbi.nlm.nih.gov/pubmed/32488989 http://dx.doi.org/10.1002/cpdd.808

Ejemplares similares

Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies
por: Zhou, Xiaofei, et al.
Publicado: (2017)

Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours
por: Moore, Kathleen N, et al.
Publicado: (2018)

Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer
por: Voss, Martin H., et al.
Publicado: (2020)

Phase I study of sapanisertib with carboplatin and paclitaxel in mTOR pathway altered solid malignancies
por: Alhalabi, Omar, et al.
Publicado: (2023)

Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies
por: Zhou, Xiaofei, et al.
Publicado: (2017)

Effect of Hemodialysis on Corrected QT Interval and QTc Dispersion
por: Sohal, P. M., et al.
Publicado: (2018)

Problems with Bazett QTc correction in paediatric screening of prolonged QTc interval
por: Andršová, Irena, et al.
Publicado: (2020)

Ketamine-induced QTc interval prolongation
por: Singh, Tejinder S. Swaran, et al.
Publicado: (2017)

Ticagrelor-Induced Prolongation of the QTc Interval
por: Ray, Avik, et al.
Publicado: (2019)

The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval
por: Lee, Ye Seung, et al.
Publicado: (2015)

Talazoparib has no clinically relevant effect on QTc interval in patients with advanced solid tumors
por: Hoffman, Justin, et al.
Publicado: (2019)

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure–response analysis
por: Fudio, Salvador, et al.
Publicado: (2020)

Corrected QT Interval (QTc) Diagnostic App for the Oncological Routine: Development Study
por: Klier, Kristina, et al.
Publicado: (2023)

A thorough QTc study demonstrates that olmesartan medoxomil does not prolong the QTc interval
por: Mendell, Jeanne, et al.
Publicado: (2015)

Effect of domperidone on the QTc interval in premature infants
por: Günlemez, A, et al.
Publicado: (2010)

QTc interval prolongation, COVID-19 and chloroquine
por: Wiwanitkit, V.
Publicado: (2020)

QTc interval-dependent body posture in pediatrics
por: Reynisson, Björn, et al.
Publicado: (2020)

A Practical Method for QTc Interval Measurement
por: De Oliveira Neto, Nestor R, et al.
Publicado: (2020)

Effect of citric-acid dialysate on the QTC-interval
por: ter Meulen, Karlien J., et al.
Publicado: (2021)

188 Evaluation of Baseline QTc Interval and Azithromycin Prescribing in an Academic Medical Center
por: Lee, Rachael, et al.
Publicado: (2014)

Effects of Peginesatide Injection on QTc Interval in Healthy Adults
por: Czerniak, Richard, et al.
Publicado: (2014)

Changes in QTc interval in long-term hemodialysis patients
por: Matsumoto, Yoshihiro, et al.
Publicado: (2019)

Individually Rate Corrected QTc Intervals in Children and Adolescents
por: Andršová, Irena, et al.
Publicado: (2019)

Azithromycin/hydroxychloroquine: QTc interval prolongation: case report
Publicado: (2020)

Relationship of QTc Interval Prolongation with Acute Ischemic Stroke
por: Amin, Osama Shukir Muhammed, et al.
Publicado: (2020)

Methadone abuse: QTc interval prolongation: case report
Publicado: (2020)

Azithromycin/hydroxychloroquine: QTc interval prolongation: case report
Publicado: (2021)

QTc interval prolongation in the patients with primary biliary cholangitis
por: Wang, Zihao, et al.
Publicado: (2021)

Lenalidomide at Therapeutic and Supratherapeutic Doses Does Not Prolong QTc Intervals in the Thorough QTc Study Conducted in Healthy Men
por: Chen, Nianhang, et al.
Publicado: (2013)

Takotsubo Cardiomyopathy and QTc Prolongation with Subsequent Improvement of QTc Interval and Resolution of Apical Ballooning: A Case Report
por: Alvarez Retamales, Violeta, et al.
Publicado: (2020)

The Effects of Moxifloxacin on QTc Interval in Healthy Korean Male Subjects
por: Moon, Seol Ju, et al.
Publicado: (2014)

Psychotropic Drugs and Prolonged QTc Interval: Does it Really that Matter?
por: Naguy, Ahmed
Publicado: (2016)

Impact of the Norepinephrine Prodrug Droxidopa on the QTc Interval in Healthy Individuals
por: White, William B., et al.
Publicado: (2017)

Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis
por: Campagna, Marcello, et al.
Publicado: (2016)

Time of the Day and Magnitude of the Effect of a Drug on the QTc Interval
por: Täubel, J, et al.
Publicado: (2017)

QTc Interval Predicts Disturbed Circadian Blood Pressure Variation
por: Yan, Liyuan, et al.
Publicado: (2020)

A statistical perspective to the QTc interval in the treatment of COVID-19
por: Mert, Kadir Ugur, et al.
Publicado: (2021)

Patients With Primary Hyperparathyroidism Have Shorter QT/QTc Intervals
por: Stewart, Latoya A, et al.
Publicado: (2021)

Influence of heart rate correction formulas on QTc interval stability
por: Andršová, Irena, et al.
Publicado: (2021)

QTc interval prolongation, inflammation, and mortality in patients with COVID-19
por: Gulletta, Simone, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rlj09aeersgi7m62uvema7kgrd