Cargando…

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum

INTRODUCTION: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. METHODS: We used NeuroToolKit and Elecsys(®) immunoassays to measure cerebrospinal fluid (CSF) amyloid‐β (Aβ)42, Aβ40, phosphorylated tau (p‐tau), total tau (t‐tau), neu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milà‐Alomà, Marta, Salvadó, Gemma, Gispert, Juan Domingo, Vilor‐Tejedor, Natalia, Grau‐Rivera, Oriol, Sala‐Vila, Aleix, Sánchez‐Benavides, Gonzalo, Arenaza‐Urquijo, Eider M., Crous‐Bou, Marta, González‐de‐Echávarri, José Maria, Minguillon, Carolina, Fauria, Karine, Simon, Maryline, Kollmorgen, Gwendlyn, Zetterberg, Henrik, Blennow, Kaj, Suárez‐Calvet, Marc, Molinuevo, José Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Featured Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586814/ https://www.ncbi.nlm.nih.gov/pubmed/32573951 http://dx.doi.org/10.1002/alz.12131

Ejemplares similares

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer’s disease
por: Grau-Rivera, Oriol, et al.
Publicado: (2021)

CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study
por: Milà-Alomà, Marta, et al.
Publicado: (2021)

Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected
por: Suárez‐Calvet, Marc, et al.
Publicado: (2020)

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study
por: Rodríguez-Fernández, Blanca, et al.
Publicado: (2022)

Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels
por: Brugulat-Serrat, Anna, et al.
Publicado: (2021)

Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum
por: Salvadó, Gemma, et al.
Publicado: (2021)

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
por: Sánchez‐Benavides, Gonzalo, et al.
Publicado: (2020)

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
por: Sala-Vila, Aleix, et al.
Publicado: (2021)

Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults
por: Akinci, Muge, et al.
Publicado: (2022)

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
por: Salvadó, Gemma, et al.
Publicado: (2022)

Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2023)

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
por: Cacciaglia, Raffaele, et al.
Publicado: (2020)

Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels
por: López-Martos, David, et al.
Publicado: (2023)

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
por: Falcón, Carles, et al.
Publicado: (2021)

Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
por: Akinci, Muge, et al.
Publicado: (2022)

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
por: Blackman, Jonathan, et al.
Publicado: (2022)

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2020)

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex
por: Cumplido-Mayoral, Irene, et al.
Publicado: (2023)

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum
por: Benedet, Andréa L., et al.
Publicado: (2021)

Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease
por: Milà-Alomà, Marta, et al.
Publicado: (2022)

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease
por: Milà-Alomà, Marta, et al.
Publicado: (2022)

Alzheimer’s disease prevention: from risk factors to early intervention
por: Crous-Bou, Marta, et al.
Publicado: (2017)

Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study
por: Fauria, Karine, et al.
Publicado: (2022)

Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
por: Johnson, Sterling C., et al.
Publicado: (2023)

Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy
por: Rodríguez-Fernández, Blanca, et al.
Publicado: (2022)

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
por: Salvadó, Gemma, et al.
Publicado: (2019)

Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation
por: Skouras, Stavros, et al.
Publicado: (2020)

Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2016)

Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease
por: Milà-Alomà, Marta, et al.
Publicado: (2019)

The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
por: Salvadó, Gemma, et al.
Publicado: (2021)

The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease
por: Molinuevo, José Luis, et al.
Publicado: (2016)

Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
por: Ciampa, Iacopo, et al.
Publicado: (2021)

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
por: Brugulat-Serrat, Anna, et al.
Publicado: (2017)

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
por: Brugulat‐Serrat, Anna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5a8u227c9a1oq76f9p0cuep5lg