IL‐7 induces sCD127 release and mCD127 downregulation in human CD8(+) T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection

The IL‐7 receptor specific α chain, CD127, can be expressed both as a membrane‐associated (mCD127) and a soluble form (sCD127), however, the mechanisms involved in their regulation remain to be defined. We first demonstrated in primary human CD8(+) T cells that IL‐7‐induced downregulation of mCD127...

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Detalles Bibliográficos
Autores principales: Côté, Sandra C., Burke Schinkel, Stephanie C., Berthoud, Tamara K., Barros, Priscila O., Sanchez‐Vidales, Maria, Davidson, April M., Crawley, Angela M., Angel, Jonathan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Immunity to infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586945/
https://www.ncbi.nlm.nih.gov/pubmed/32390135
http://dx.doi.org/10.1002/eji.201948453

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