CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with t...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586983/
https://www.ncbi.nlm.nih.gov/pubmed/32502279
http://dx.doi.org/10.1002/eji.201948341
Descripción
Sumario:RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes. [Image: see text]

Ejemplares similares