CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with t...

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Detalles Bibliográficos
Autores principales: Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586983/
https://www.ncbi.nlm.nih.gov/pubmed/32502279
http://dx.doi.org/10.1002/eji.201948341
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author Silva‐Cardoso, Sandra C.
Tao, Weiyang
Fernández, Beatriz Malvar
Boes, Marianne
Radstake, Timothy R.D.J.
Pandit, Aridaman
author_facet Silva‐Cardoso, Sandra C.
Tao, Weiyang
Fernández, Beatriz Malvar
Boes, Marianne
Radstake, Timothy R.D.J.
Pandit, Aridaman
author_sort Silva‐Cardoso, Sandra C.
collection PubMed
description RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes. [Image: see text]
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spelling pubmed-75869832020-10-30 CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells Silva‐Cardoso, Sandra C. Tao, Weiyang Fernández, Beatriz Malvar Boes, Marianne Radstake, Timothy R.D.J. Pandit, Aridaman Eur J Immunol Letters to the Editor RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes. [Image: see text] John Wiley and Sons Inc. 2020-07-10 2020-10 /pmc/articles/PMC7586983/ /pubmed/32502279 http://dx.doi.org/10.1002/eji.201948341 Text en © 2020 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letters to the Editor
Silva‐Cardoso, Sandra C.
Tao, Weiyang
Fernández, Beatriz Malvar
Boes, Marianne
Radstake, Timothy R.D.J.
Pandit, Aridaman
CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title_full CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title_fullStr CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title_full_unstemmed CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title_short CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
title_sort cxcl4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586983/
https://www.ncbi.nlm.nih.gov/pubmed/32502279
http://dx.doi.org/10.1002/eji.201948341
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