Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst

[Image: see text] A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN(3) pincer complex. Th...

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Autores principales: Hofmann, Natalie, Homberg, Leonard, Hultzsch, Kai C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587143/
https://www.ncbi.nlm.nih.gov/pubmed/32970449
http://dx.doi.org/10.1021/acs.orglett.0c02905
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author Hofmann, Natalie
Homberg, Leonard
Hultzsch, Kai C.
author_facet Hofmann, Natalie
Homberg, Leonard
Hultzsch, Kai C.
author_sort Hofmann, Natalie
collection PubMed
description [Image: see text] A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN(3) pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.
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spelling pubmed-75871432020-10-27 Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst Hofmann, Natalie Homberg, Leonard Hultzsch, Kai C. Org Lett [Image: see text] A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN(3) pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required. American Chemical Society 2020-09-24 2020-10-16 /pmc/articles/PMC7587143/ /pubmed/32970449 http://dx.doi.org/10.1021/acs.orglett.0c02905 Text en This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Hofmann, Natalie
Homberg, Leonard
Hultzsch, Kai C.
Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title_full Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title_fullStr Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title_full_unstemmed Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title_short Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN(3) Pincer Catalyst
title_sort synthesis of tetrahydroquinolines via borrowing hydrogen methodology using a manganese pn(3) pincer catalyst
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587143/
https://www.ncbi.nlm.nih.gov/pubmed/32970449
http://dx.doi.org/10.1021/acs.orglett.0c02905
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