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Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT

The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like...

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Autores principales: Desissaire, Sylvia, Pollreisz, Andreas, Sedova, Aleksandra, Hajdu, Dorottya, Datlinger, Felix, Steiner, Stefan, Vass, Clemens, Schwarzhans, Florian, Fischer, Georg, Pircher, Michael, Schmidt-Erfurth, Ursula, Hitzenberger, Christoph K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587266/
https://www.ncbi.nlm.nih.gov/pubmed/33149966
http://dx.doi.org/10.1364/BOE.402475
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author Desissaire, Sylvia
Pollreisz, Andreas
Sedova, Aleksandra
Hajdu, Dorottya
Datlinger, Felix
Steiner, Stefan
Vass, Clemens
Schwarzhans, Florian
Fischer, Georg
Pircher, Michael
Schmidt-Erfurth, Ursula
Hitzenberger, Christoph K.
author_facet Desissaire, Sylvia
Pollreisz, Andreas
Sedova, Aleksandra
Hajdu, Dorottya
Datlinger, Felix
Steiner, Stefan
Vass, Clemens
Schwarzhans, Florian
Fischer, Georg
Pircher, Michael
Schmidt-Erfurth, Ursula
Hitzenberger, Christoph K.
author_sort Desissaire, Sylvia
collection PubMed
description The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot study, we used a state-of-the-art polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker to analyze the RNFL birefringence in patients with glaucoma, DR, and in age-matched healthy controls. We recorded 3D PS-OCT raster scans of the optic nerve head area and high-quality averaged circumpapillary PS-OCT scans, from which RNFL thickness, retardation and birefringence were derived. The precision of birefringence measurements was 0.005°/µm. As compared to healthy controls, glaucoma patients showed a slightly reduced birefringence (0.129 vs. 0.135°/µm), although not statistically significant. The DR patients, however, showed a stronger reduction of RNFL birefringence (0.103 vs. 0.135°/µm) which was highly significant. This result might open new avenues into early diagnosis of DR and related neurologic changes.
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spelling pubmed-75872662020-11-03 Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT Desissaire, Sylvia Pollreisz, Andreas Sedova, Aleksandra Hajdu, Dorottya Datlinger, Felix Steiner, Stefan Vass, Clemens Schwarzhans, Florian Fischer, Georg Pircher, Michael Schmidt-Erfurth, Ursula Hitzenberger, Christoph K. Biomed Opt Express Article The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot study, we used a state-of-the-art polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker to analyze the RNFL birefringence in patients with glaucoma, DR, and in age-matched healthy controls. We recorded 3D PS-OCT raster scans of the optic nerve head area and high-quality averaged circumpapillary PS-OCT scans, from which RNFL thickness, retardation and birefringence were derived. The precision of birefringence measurements was 0.005°/µm. As compared to healthy controls, glaucoma patients showed a slightly reduced birefringence (0.129 vs. 0.135°/µm), although not statistically significant. The DR patients, however, showed a stronger reduction of RNFL birefringence (0.103 vs. 0.135°/µm) which was highly significant. This result might open new avenues into early diagnosis of DR and related neurologic changes. Optical Society of America 2020-09-10 /pmc/articles/PMC7587266/ /pubmed/33149966 http://dx.doi.org/10.1364/BOE.402475 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
spellingShingle Article
Desissaire, Sylvia
Pollreisz, Andreas
Sedova, Aleksandra
Hajdu, Dorottya
Datlinger, Felix
Steiner, Stefan
Vass, Clemens
Schwarzhans, Florian
Fischer, Georg
Pircher, Michael
Schmidt-Erfurth, Ursula
Hitzenberger, Christoph K.
Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title_full Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title_fullStr Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title_full_unstemmed Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title_short Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
title_sort analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive oct
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587266/
https://www.ncbi.nlm.nih.gov/pubmed/33149966
http://dx.doi.org/10.1364/BOE.402475
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