Cargando…
Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587266/ https://www.ncbi.nlm.nih.gov/pubmed/33149966 http://dx.doi.org/10.1364/BOE.402475 |
_version_ | 1783600149178613760 |
---|---|
author | Desissaire, Sylvia Pollreisz, Andreas Sedova, Aleksandra Hajdu, Dorottya Datlinger, Felix Steiner, Stefan Vass, Clemens Schwarzhans, Florian Fischer, Georg Pircher, Michael Schmidt-Erfurth, Ursula Hitzenberger, Christoph K. |
author_facet | Desissaire, Sylvia Pollreisz, Andreas Sedova, Aleksandra Hajdu, Dorottya Datlinger, Felix Steiner, Stefan Vass, Clemens Schwarzhans, Florian Fischer, Georg Pircher, Michael Schmidt-Erfurth, Ursula Hitzenberger, Christoph K. |
author_sort | Desissaire, Sylvia |
collection | PubMed |
description | The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot study, we used a state-of-the-art polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker to analyze the RNFL birefringence in patients with glaucoma, DR, and in age-matched healthy controls. We recorded 3D PS-OCT raster scans of the optic nerve head area and high-quality averaged circumpapillary PS-OCT scans, from which RNFL thickness, retardation and birefringence were derived. The precision of birefringence measurements was 0.005°/µm. As compared to healthy controls, glaucoma patients showed a slightly reduced birefringence (0.129 vs. 0.135°/µm), although not statistically significant. The DR patients, however, showed a stronger reduction of RNFL birefringence (0.103 vs. 0.135°/µm) which was highly significant. This result might open new avenues into early diagnosis of DR and related neurologic changes. |
format | Online Article Text |
id | pubmed-7587266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-75872662020-11-03 Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT Desissaire, Sylvia Pollreisz, Andreas Sedova, Aleksandra Hajdu, Dorottya Datlinger, Felix Steiner, Stefan Vass, Clemens Schwarzhans, Florian Fischer, Georg Pircher, Michael Schmidt-Erfurth, Ursula Hitzenberger, Christoph K. Biomed Opt Express Article The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot study, we used a state-of-the-art polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker to analyze the RNFL birefringence in patients with glaucoma, DR, and in age-matched healthy controls. We recorded 3D PS-OCT raster scans of the optic nerve head area and high-quality averaged circumpapillary PS-OCT scans, from which RNFL thickness, retardation and birefringence were derived. The precision of birefringence measurements was 0.005°/µm. As compared to healthy controls, glaucoma patients showed a slightly reduced birefringence (0.129 vs. 0.135°/µm), although not statistically significant. The DR patients, however, showed a stronger reduction of RNFL birefringence (0.103 vs. 0.135°/µm) which was highly significant. This result might open new avenues into early diagnosis of DR and related neurologic changes. Optical Society of America 2020-09-10 /pmc/articles/PMC7587266/ /pubmed/33149966 http://dx.doi.org/10.1364/BOE.402475 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
spellingShingle | Article Desissaire, Sylvia Pollreisz, Andreas Sedova, Aleksandra Hajdu, Dorottya Datlinger, Felix Steiner, Stefan Vass, Clemens Schwarzhans, Florian Fischer, Georg Pircher, Michael Schmidt-Erfurth, Ursula Hitzenberger, Christoph K. Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title | Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title_full | Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title_fullStr | Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title_full_unstemmed | Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title_short | Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT |
title_sort | analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive oct |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587266/ https://www.ncbi.nlm.nih.gov/pubmed/33149966 http://dx.doi.org/10.1364/BOE.402475 |
work_keys_str_mv | AT desissairesylvia analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT pollreiszandreas analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT sedovaaleksandra analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT hajdudorottya analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT datlingerfelix analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT steinerstefan analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT vassclemens analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT schwarzhansflorian analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT fischergeorg analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT pirchermichael analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT schmidterfurthursula analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct AT hitzenbergerchristophk analysisofretinalnervefiberlayerbirefringenceinpatientswithglaucomaanddiabeticretinopathybypolarizationsensitiveoct |