Cargando…

Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases

Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2′deoxyadenosine to 2′deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with membrane proteins, such as CD26 and adenosine receptors, f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kutryb-Zajac, Barbara, Mierzejewska, Paulina, Slominska, Ewa M., Smolenski, Ryszard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587364/ https://www.ncbi.nlm.nih.gov/pubmed/33053898 http://dx.doi.org/10.3390/molecules25204652

Ejemplares similares

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor‐dependent mechanisms
por: Kutryb‐Zajac, Barbara, et al.
Publicado: (2018)

Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2021)

The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2022)

4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)—A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis
por: Koszalka, Patrycja, et al.
Publicado: (2022)

Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
por: Braczko, Alicja, et al.
Publicado: (2022)

The new insight into extracellular NAD(+) degradation‐the contribution of CD38 and CD73 in calcific aortic valve disease
por: Jablonska, Patrycja, et al.
Publicado: (2021)

Differences in Extracellular NAD(+) and NMN Metabolism on the Surface of Vascular Endothelial Cells
por: Jablonska, Patrycja, et al.
Publicado: (2022)

Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a Mouse
por: Mierzejewska, Paulina, et al.
Publicado: (2023)

CoCl(2)-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2022)

Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure
por: Jedrzejewska, Agata, et al.
Publicado: (2022)

Impaired l-arginine metabolism marks endothelial dysfunction in CD73-deficient mice
por: Mierzejewska, P., et al.
Publicado: (2019)

An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite
por: Mierzejewska, Paulina, et al.
Publicado: (2021)

Nucleotide ecto-enzyme metabolic pattern and spatial distribution in calcific aortic valve disease; its relation to pathological changes and clinical presentation
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2019)

Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019
por: Jedrzejewska, Agata, et al.
Publicado: (2023)

AMP Deaminase 1 Gene Polymorphism and Heart Disease—A Genetic Association That Highlights New Treatment
por: Smolenski, Ryszard T., et al.
Publicado: (2014)

Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production
por: Zabielska-Kaczorowska, Magdalena A., et al.
Publicado: (2023)

National experience with adenosine deaminase deficiency related SCID in Polish children
por: Dąbrowska-Leonik, Nel, et al.
Publicado: (2023)

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer
por: Zhulai, Galina, et al.
Publicado: (2022)

High Throughput Procedure for Comparative Analysis of In Vivo Cardiac Glucose or Amino Acids Use in Cardiovascular Pathologies and Pharmacological Treatments
por: Tomczyk, Marta, et al.
Publicado: (2021)

Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2016)

Rosiglitazone Ameliorates Cardiac and Skeletal Muscle Dysfunction by Correction of Energetics in Huntington’s Disease
por: Tomczyk, Marta, et al.
Publicado: (2022)

Purine Nucleotides Metabolism and Signaling in Huntington’s Disease: Search for a Target for Novel Therapies
por: Tomczyk, Marta, et al.
Publicado: (2021)

Adenosine deaminase deficiency: a review
por: Flinn, Aisling M., et al.
Publicado: (2018)

Adenosine deaminase activity in leukaemia.
por: Smyth, J. F., et al.
Publicado: (1975)

The deficiency of adenosine deaminase type 2-results of therapeutic intervention
por: Ombrello, A, et al.
Publicado: (2015)

Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats
por: El-Said, Karim Samy, et al.
Publicado: (2022)

Urogenital Abnormalities in Adenosine Deaminase Deficiency
por: Pajno, Roberta, et al.
Publicado: (2020)

Neutropenia in patients with adenosine deaminase deficiency
por: Kim, Vy HD, et al.
Publicado: (2014)

Adenosine deaminase in exudative pleural effusions
por: Wiwanitkit, Somsri, et al.
Publicado: (2014)

Combined Immunodeficiency Disease and Adenosine Deaminase Deficiency. A Molecular Defect
por: Baumgarten, Alexander
Publicado: (1976)

Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours.
por: Jackson, R. C., et al.
Publicado: (1978)

Diversity of adenosine deaminase in children with EBV-related diseases
por: Shi, Ting, et al.
Publicado: (2022)

Adenosine deaminase acting on RNA 1 (ADAR1) as crucial regulators in cardiovascular diseases: structures, pathogenesis, and potential therapeutic approach
por: Chen, Jieying, et al.
Publicado: (2023)

Blocking cholesterol formation and turnover improves cellular and mitochondria function in murine heart microvascular endothelial cells and cardiomyocytes
por: Braczko, Alicja, et al.
Publicado: (2023)

Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances
por: Li, Gen, et al.
Publicado: (2015)

Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations
por: Tian, Xiaopian, et al.
Publicado: (2018)

Role of adenosine deaminase 2 gene variants in pediatric deficiency of adenosine deaminase 2: A structural biological approach
por: Zervou, Maria I., et al.
Publicado: (2020)

Role of adenosine deaminase 2 gene variants in pediatric deficiency of adenosine deaminase 2: A structural biological approach
por: Zervou, Maria I., et al.
Publicado: (2021)

Performance of the quantification of adenosine deaminase and determination of the lactate dehydrogenase/adenosine deaminase ratio for the diagnosis of pleural tuberculosis in children and adolescents
por: Vieira, Julia Lima, et al.
Publicado: (2021)

Adenosine and adenosine receptors: Newer therapeutic perspective
por: Manjunath, S., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_n7lno0o2cggbc9ef43fq42kuj0