IP(7)-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP(7) (isomer 5-PP-IP(5)) in driving fungal virulence; however, the mechanism of action remains elusive....

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Detalles Bibliográficos
Autores principales: Desmarini, Desmarini, Lev, Sophie, Furkert, David, Crossett, Ben, Saiardi, Adolfo, Kaufman-Francis, Keren, Li, Cecilia, Sorrell, Tania C., Wilkinson-White, Lorna, Matthews, Jacqueline, Fiedler, Dorothea, Djordjevic, Julianne Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587432/
https://www.ncbi.nlm.nih.gov/pubmed/33082258
http://dx.doi.org/10.1128/mBio.01920-20

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