Cargando…

Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model

A ‘remedy for all’ natural product widely known in the Korean Peninsula is called Panax Ginseng Meyer. Globalization represents a persistent risk to the ozone layer, leading to bountiful amounts of Ultra-Violet B beams (UVB). The variety in human skin hues is ascribed to the characteristic color cal...

Descripción completa

Detalles Bibliográficos
Autores principales: Saba, Evelyn, Kim, Seung-Hyung, Lee, Yuan Yee, Kim, Hyun-Kyoung, Roh, Seong-Soo, Kwak, Yi-Seong, Park, Chae-Kyu, Kim, Sung-Dae, Rhee, Man Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587592/
https://www.ncbi.nlm.nih.gov/pubmed/33081281
http://dx.doi.org/10.3390/molecules25204755
_version_ 1783600206085881856
author Saba, Evelyn
Kim, Seung-Hyung
Lee, Yuan Yee
Kim, Hyun-Kyoung
Roh, Seong-Soo
Kwak, Yi-Seong
Park, Chae-Kyu
Kim, Sung-Dae
Rhee, Man Hee
author_facet Saba, Evelyn
Kim, Seung-Hyung
Lee, Yuan Yee
Kim, Hyun-Kyoung
Roh, Seong-Soo
Kwak, Yi-Seong
Park, Chae-Kyu
Kim, Sung-Dae
Rhee, Man Hee
author_sort Saba, Evelyn
collection PubMed
description A ‘remedy for all’ natural product widely known in the Korean Peninsula is called Panax Ginseng Meyer. Globalization represents a persistent risk to the ozone layer, leading to bountiful amounts of Ultra-Violet B beams (UVB). The variety in human skin hues is ascribed to the characteristic color called Melanin. However, Melanin overproduction due to UVB beams promotes skin staining and tumorigenesis, a process called photo aging, which damages skin quality. To assess the effects of Korean Red Ginseng Oil (KGO) on photo aging, the murine melanoma cell lines B16/F10 were used in vitro and HRM-2 hairless mice exposed to UVB were studied in vivo. Our results revealed that KGO reduced tyrosinase activity and melanin production in B16/F10 cells along with the suppression of upstream factors involved in the melanin production pathway, both transcriptionally and transitionally. In the in vivo studies, KGO suppressed the expression of Matrix Metalloproteinase (MMP) and Interleukins along with a reduction of depth in wrinkle formation and reduced collagen degradation. Moreover, the feed intake and feed efficiency ratio that decreased as a result of UVB exposure was also improved by KGO treatment. In light of our results, we conclude that KGO can have considerable benefits due to its various properties of natural skin enhancement.
format Online
Article
Text
id pubmed-7587592
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75875922020-10-29 Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model Saba, Evelyn Kim, Seung-Hyung Lee, Yuan Yee Kim, Hyun-Kyoung Roh, Seong-Soo Kwak, Yi-Seong Park, Chae-Kyu Kim, Sung-Dae Rhee, Man Hee Molecules Article A ‘remedy for all’ natural product widely known in the Korean Peninsula is called Panax Ginseng Meyer. Globalization represents a persistent risk to the ozone layer, leading to bountiful amounts of Ultra-Violet B beams (UVB). The variety in human skin hues is ascribed to the characteristic color called Melanin. However, Melanin overproduction due to UVB beams promotes skin staining and tumorigenesis, a process called photo aging, which damages skin quality. To assess the effects of Korean Red Ginseng Oil (KGO) on photo aging, the murine melanoma cell lines B16/F10 were used in vitro and HRM-2 hairless mice exposed to UVB were studied in vivo. Our results revealed that KGO reduced tyrosinase activity and melanin production in B16/F10 cells along with the suppression of upstream factors involved in the melanin production pathway, both transcriptionally and transitionally. In the in vivo studies, KGO suppressed the expression of Matrix Metalloproteinase (MMP) and Interleukins along with a reduction of depth in wrinkle formation and reduced collagen degradation. Moreover, the feed intake and feed efficiency ratio that decreased as a result of UVB exposure was also improved by KGO treatment. In light of our results, we conclude that KGO can have considerable benefits due to its various properties of natural skin enhancement. MDPI 2020-10-16 /pmc/articles/PMC7587592/ /pubmed/33081281 http://dx.doi.org/10.3390/molecules25204755 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saba, Evelyn
Kim, Seung-Hyung
Lee, Yuan Yee
Kim, Hyun-Kyoung
Roh, Seong-Soo
Kwak, Yi-Seong
Park, Chae-Kyu
Kim, Sung-Dae
Rhee, Man Hee
Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title_full Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title_fullStr Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title_full_unstemmed Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title_short Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model
title_sort anti-melanogenic effects of korean red ginseng oil in an ultraviolet b-induced hairless mouse model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587592/
https://www.ncbi.nlm.nih.gov/pubmed/33081281
http://dx.doi.org/10.3390/molecules25204755
work_keys_str_mv AT sabaevelyn antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT kimseunghyung antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT leeyuanyee antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT kimhyunkyoung antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT rohseongsoo antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT kwakyiseong antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT parkchaekyu antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT kimsungdae antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel
AT rheemanhee antimelanogeniceffectsofkoreanredginsengoilinanultravioletbinducedhairlessmousemodel