Cargando…

Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID

Background and objectives: Common variable immunodeficiency (CVID) is the most prevalent antibody impairment. It is characterized by failure in immunoglobulin and protective antibody generation and defined by an increased tendency toward bacterial infections, autoimmunity, and malignancy. Most CVID...

Descripción completa

Detalles Bibliográficos
Autores principales: Amato, Giuliana, Vita, Federica, Quattrocchi, Paolina, Minciullo, Paola Lucia, Pioggia, Giovanni, Gangemi, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587593/
https://www.ncbi.nlm.nih.gov/pubmed/33081305
http://dx.doi.org/10.3390/molecules25204760
_version_ 1783600206314471424
author Amato, Giuliana
Vita, Federica
Quattrocchi, Paolina
Minciullo, Paola Lucia
Pioggia, Giovanni
Gangemi, Sebastiano
author_facet Amato, Giuliana
Vita, Federica
Quattrocchi, Paolina
Minciullo, Paola Lucia
Pioggia, Giovanni
Gangemi, Sebastiano
author_sort Amato, Giuliana
collection PubMed
description Background and objectives: Common variable immunodeficiency (CVID) is the most prevalent antibody impairment. It is characterized by failure in immunoglobulin and protective antibody generation and defined by an increased tendency toward bacterial infections, autoimmunity, and malignancy. Most CVID diagnoses do not follow a classical Mendelian pattern of inheritance. In recent years, CVID has been considered an epigenetic phenomenon in the majority of cases, overtaking previous monogenetic and/or polygenetic theories. The aim of this study was to review the role of microRNAs (miRNAs) in CVID, focusing on the involvement of the same miRNAs in various non-infectious clinical complications of CVID, mainly autoimmunity and/or cancer. Materials and Methods: A bibliographic search of the scientific literature was carried out independently by two researchers in scientific databases and search engines. The MeSH terms “microRNAs” and “common variable immunodeficiency” were used. All research articles from inception to May 2020 were considered. Results: The literature data showed the involvement of two miRNAs in primary immunodeficiency: miR-142 and miR-155. Both of these miRNAs have been investigated through mice models, in which miR-142 and miR-155 were deleted. These knock-out (KO) mice models showed phenotypic analogies to CVID patients with hypogammaglobulinemia, adaptive immunodeficiency, polyclonal proliferation, lung disease, and enteric inflammation. miR-142 and miR-155 have been found to be involved in the following autoimmune and neoplastic clinical complications of CVID: Gastric cancer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, natural killer/Tcell lymphoma (NKTCL), and immune thrombocytopenia. Conclusions: miR-142 and miR-155 deregulation leads to similar CVID phenotypesin KO mice models. Although no data are available on the involvement of these miRNAs in human CVID, their dysregulation has been detected in human CVID comorbidities. The literature data show that miRNA sequences in murine models are comparable to those in humans; therefore, miR-142 and miR-155 involvement in human CVID could be hypothesized.
format Online
Article
Text
id pubmed-7587593
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75875932020-10-29 Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID Amato, Giuliana Vita, Federica Quattrocchi, Paolina Minciullo, Paola Lucia Pioggia, Giovanni Gangemi, Sebastiano Molecules Review Background and objectives: Common variable immunodeficiency (CVID) is the most prevalent antibody impairment. It is characterized by failure in immunoglobulin and protective antibody generation and defined by an increased tendency toward bacterial infections, autoimmunity, and malignancy. Most CVID diagnoses do not follow a classical Mendelian pattern of inheritance. In recent years, CVID has been considered an epigenetic phenomenon in the majority of cases, overtaking previous monogenetic and/or polygenetic theories. The aim of this study was to review the role of microRNAs (miRNAs) in CVID, focusing on the involvement of the same miRNAs in various non-infectious clinical complications of CVID, mainly autoimmunity and/or cancer. Materials and Methods: A bibliographic search of the scientific literature was carried out independently by two researchers in scientific databases and search engines. The MeSH terms “microRNAs” and “common variable immunodeficiency” were used. All research articles from inception to May 2020 were considered. Results: The literature data showed the involvement of two miRNAs in primary immunodeficiency: miR-142 and miR-155. Both of these miRNAs have been investigated through mice models, in which miR-142 and miR-155 were deleted. These knock-out (KO) mice models showed phenotypic analogies to CVID patients with hypogammaglobulinemia, adaptive immunodeficiency, polyclonal proliferation, lung disease, and enteric inflammation. miR-142 and miR-155 have been found to be involved in the following autoimmune and neoplastic clinical complications of CVID: Gastric cancer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, natural killer/Tcell lymphoma (NKTCL), and immune thrombocytopenia. Conclusions: miR-142 and miR-155 deregulation leads to similar CVID phenotypesin KO mice models. Although no data are available on the involvement of these miRNAs in human CVID, their dysregulation has been detected in human CVID comorbidities. The literature data show that miRNA sequences in murine models are comparable to those in humans; therefore, miR-142 and miR-155 involvement in human CVID could be hypothesized. MDPI 2020-10-16 /pmc/articles/PMC7587593/ /pubmed/33081305 http://dx.doi.org/10.3390/molecules25204760 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amato, Giuliana
Vita, Federica
Quattrocchi, Paolina
Minciullo, Paola Lucia
Pioggia, Giovanni
Gangemi, Sebastiano
Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title_full Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title_fullStr Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title_full_unstemmed Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title_short Involvement of miR-142 and miR-155 in Non-Infectious Complications of CVID
title_sort involvement of mir-142 and mir-155 in non-infectious complications of cvid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587593/
https://www.ncbi.nlm.nih.gov/pubmed/33081305
http://dx.doi.org/10.3390/molecules25204760
work_keys_str_mv AT amatogiuliana involvementofmir142andmir155innoninfectiouscomplicationsofcvid
AT vitafederica involvementofmir142andmir155innoninfectiouscomplicationsofcvid
AT quattrocchipaolina involvementofmir142andmir155innoninfectiouscomplicationsofcvid
AT minciullopaolalucia involvementofmir142andmir155innoninfectiouscomplicationsofcvid
AT pioggiagiovanni involvementofmir142andmir155innoninfectiouscomplicationsofcvid
AT gangemisebastiano involvementofmir142andmir155innoninfectiouscomplicationsofcvid