Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

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The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenesis, antiviral immunity, and treatment response to...

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Detalles Bibliográficos
Autores principales: Fiege, Jessica K., Thiede, Joshua M., Nanda, Hezkiel, Matchett, William E., Moore, Patrick J., Montanari, Noe Rico, Thielen, Beth K., Daniel, Jerry, Stanley, Emma, Hunter, Ryan C., Menachery, Vineet D., Shen, Steven S., Bold, Tyler D., Langlois, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587775/
https://www.ncbi.nlm.nih.gov/pubmed/33106802
http://dx.doi.org/10.1101/2020.10.19.343954
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