Restriction of SARS-CoV-2 Replication by Targeting Programmed −1 Ribosomal Frameshifting In Vitro

Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires programmed −1 ribosomal frameshifting (−1 PRF) promoted by an RNA pseudoknot. The extent to which SARS-CoV-2 replication may be sensitive to changes in −1 PRF efficiency is currently...

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Detalles Bibliográficos
Autores principales: Sun, Yu, Abriola, Laura, Surovtseva, Yulia V., Lindenbach, Brett D., Guo, Junjie U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587830/
https://www.ncbi.nlm.nih.gov/pubmed/33106809
http://dx.doi.org/10.1101/2020.10.21.349225

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