Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities

In the current study, further chemical investigation of the fruiting bodies of Fomes officinalis led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (1–7). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR...

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Autores principales: Han, Jianxin, Liu, Wei, Li, Miaomiao, Gu, Yanpei, Zhang, Ying, Yuan, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587970/
https://www.ncbi.nlm.nih.gov/pubmed/33086725
http://dx.doi.org/10.3390/molecules25204807
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author Han, Jianxin
Liu, Wei
Li, Miaomiao
Gu, Yanpei
Zhang, Ying
Yuan, Tao
author_facet Han, Jianxin
Liu, Wei
Li, Miaomiao
Gu, Yanpei
Zhang, Ying
Yuan, Tao
author_sort Han, Jianxin
collection PubMed
description In the current study, further chemical investigation of the fruiting bodies of Fomes officinalis led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (1–7). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds 1−3 possessed an unusual C-23 spirostructure moiety, while compounds 4−7 had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds 3 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).
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spelling pubmed-75879702020-10-29 Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities Han, Jianxin Liu, Wei Li, Miaomiao Gu, Yanpei Zhang, Ying Yuan, Tao Molecules Article In the current study, further chemical investigation of the fruiting bodies of Fomes officinalis led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (1–7). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds 1−3 possessed an unusual C-23 spirostructure moiety, while compounds 4−7 had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds 3 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2). MDPI 2020-10-19 /pmc/articles/PMC7587970/ /pubmed/33086725 http://dx.doi.org/10.3390/molecules25204807 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Jianxin
Liu, Wei
Li, Miaomiao
Gu, Yanpei
Zhang, Ying
Yuan, Tao
Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title_full Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title_fullStr Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title_full_unstemmed Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title_short Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
title_sort lanostane triterpenoids from the fruiting bodies of fomes officinalis and their anti-inflammatory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587970/
https://www.ncbi.nlm.nih.gov/pubmed/33086725
http://dx.doi.org/10.3390/molecules25204807
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