Cargando…

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cells, and as such constitute attractive targets for t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tilayov, Tal, Hingaly, Tal, Greenshpan, Yariv, Cohen, Shira, Akabayov, Barak, Gazit, Roi, Papo, Niv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588011/ https://www.ncbi.nlm.nih.gov/pubmed/33096693 http://dx.doi.org/10.3390/molecules25204850

Ejemplares similares

Mapping Whole-Transcriptome Splicing in Mouse Hematopoietic Stem Cells
por: Goldstein, Oron, et al.
Publicado: (2016)

Neat1 in hematopoietic stem cells
por: Fallik, Noam, et al.
Publicado: (2017)

Identification of immune-activated hematopoietic stem cells
por: Bujanover, Nir, et al.
Publicado: (2018)

N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion
por: Iraqi, Muhammed, et al.
Publicado: (2020)

The Contribution of the Minimal Promoter Element to the Activity of Synthetic Promoters Mediating CAR Expression in the Tumor Microenvironment
por: Greenshpan, Yariv, et al.
Publicado: (2022)

Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer
por: Rosenfeld, Lior, et al.
Publicado: (2020)

Synthetic promoters to induce immune-effectors into the tumor microenvironment
por: Greenshpan, Yariv, et al.
Publicado: (2021)

High throughput screen for the improvement of inducible promoters for tumor microenvironment cues
por: Sharabi, Omri, et al.
Publicado: (2022)

Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy
por: Shlamkovich, Tomer, et al.
Publicado: (2017)

Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma
por: Iraqi, Muhammed, et al.
Publicado: (2022)

Engineered ligand‐based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis
por: Kapur, Shiven, et al.
Publicado: (2017)

DnaG Primase—A Target for the Development of Novel Antibacterial Agents
por: Ilic, Stefan, et al.
Publicado: (2018)

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
por: Arkadash, Valeria, et al.
Publicado: (2018)

Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis
por: Tam, Benjamin, et al.
Publicado: (2019)

Metabolite medicine offers a path beyond lists of metabolites
por: Shaham-Niv, Shira, et al.
Publicado: (2021)

Using evolutionary data to make sense of macromolecules with a “face‐lifted” ConSurf
por: Yariv, Barak, et al.
Publicado: (2023)

Mapping the splicing landscape of the human immune system
por: Ner-Gaon, Hadas, et al.
Publicado: (2023)

Saliva metabolome alterations after acute stress
por: Morgan, Liat, et al.
Publicado: (2022)

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity
por: Ottolenghi, Aner, et al.
Publicado: (2021)

Antibodies towards Tyrosine Amyloid-Like Fibrils Allow Toxicity Modulation and Cellular Imaging of the Assemblies
por: Zaguri, Dor, et al.
Publicado: (2018)

Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex
por: Akabayov, Sabine R., et al.
Publicado: (2014)

Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition
por: Galindo-Murillo, Rodrigo, et al.
Publicado: (2020)

Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies
por: Shaham-Niv, Shira, et al.
Publicado: (2015)

Gene Duplication of the Zebrafish kit ligand and Partitioning of Melanocyte Development Functions to kit ligand a
por: Hultman, Keith A, et al.
Publicado: (2007)

Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells
por: Gazit, Roi, et al.
Publicado: (2013)

Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations
por: Sade, Dorin, et al.
Publicado: (2018)

Engineering Lineage Potency and Plasticity of Stem Cells using Epigenetic Molecules
por: Dhaliwal, Anandika, et al.
Publicado: (2018)

Functional binding of PD1 ligands predicts response to anti-PD1 treatment in patients with cancer
por: Kaufman, Bar, et al.
Publicado: (2023)

Developing a tool to preserve eye contact with patients undergoing colonoscopy for pain monitoring
por: Niv, Yaron, et al.
Publicado: (2012)

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering
por: Heckel, Franziska, et al.
Publicado: (2022)

Bone stem cell mediated gene therapy and tissue engineering
por: Gazit, D
Publicado: (2001)

Activation of the μ‐opioid receptor by alicyclic fentanyls: Changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure
por: Åstrand, Anna, et al.
Publicado: (2020)

Rapid activation of hematopoietic stem cells
por: Thapa, Roshina, et al.
Publicado: (2023)

Height, but not binding epitope, affects the potency of synthetic TCR agonists
por: Wilhelm, Kiera B., et al.
Publicado: (2021)

Height, but not binding epitope, affects the potency of synthetic TCR agonists
por: Wilhelm, Kiera B., et al.
Publicado: (2021)

Impact of macromolecular crowding on DNA replication
por: Akabayov, Barak, et al.
Publicado: (2013)

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy
por: Yosef, Gal, et al.
Publicado: (2021)

NMR-Fragment Based Virtual Screening: A Brief Overview
por: Singh, Meenakshi, et al.
Publicado: (2018)

Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency
por: Guzelj, Samo, et al.
Publicado: (2022)

Identification of DNA primase inhibitors via a combined fragment-based and virtual screening
por: Ilic, Stefan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ia3qunb71dd88i0noo4c10h1q8