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The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer

Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing...

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Detalles Bibliográficos
Autores principales: Guo, Rui, Chen, Yu, Borgard, Heather, Jijiwa, Mayumi, Nasu, Masaki, He, Min, Deng, Youping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588012/
https://www.ncbi.nlm.nih.gov/pubmed/33096860
http://dx.doi.org/10.3390/molecules25204864
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author Guo, Rui
Chen, Yu
Borgard, Heather
Jijiwa, Mayumi
Nasu, Masaki
He, Min
Deng, Youping
author_facet Guo, Rui
Chen, Yu
Borgard, Heather
Jijiwa, Mayumi
Nasu, Masaki
He, Min
Deng, Youping
author_sort Guo, Rui
collection PubMed
description Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing, involving cancer occurrence, proliferation, migration, and apoptosis. Breast cancer has seriously affected the safety and quality of life of human beings worldwide and has become a significant public health problem in modern society, with an especially high incidence among women. Therefore, the issue has inspired scientific researchers to study the link between lipids and breast cancer. This article reviews the research progress of lipidomics, the biological characteristics of lipid molecules, and the relationship between some lipids and cancer drug resistance. Furthermore, this work summarizes the lipid molecules related to breast cancer diagnosis and prognosis, and then it clarifies their impact on the occurrence and development of breast cancer The discussion revolves around the current research hotspot long-chain non-coding RNAs (lncRNAs), summarizes and explains their impact on tumor lipid metabolism, and provides more scientific basis for future cancer research studies.
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spelling pubmed-75880122020-10-29 The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer Guo, Rui Chen, Yu Borgard, Heather Jijiwa, Mayumi Nasu, Masaki He, Min Deng, Youping Molecules Review Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing, involving cancer occurrence, proliferation, migration, and apoptosis. Breast cancer has seriously affected the safety and quality of life of human beings worldwide and has become a significant public health problem in modern society, with an especially high incidence among women. Therefore, the issue has inspired scientific researchers to study the link between lipids and breast cancer. This article reviews the research progress of lipidomics, the biological characteristics of lipid molecules, and the relationship between some lipids and cancer drug resistance. Furthermore, this work summarizes the lipid molecules related to breast cancer diagnosis and prognosis, and then it clarifies their impact on the occurrence and development of breast cancer The discussion revolves around the current research hotspot long-chain non-coding RNAs (lncRNAs), summarizes and explains their impact on tumor lipid metabolism, and provides more scientific basis for future cancer research studies. MDPI 2020-10-21 /pmc/articles/PMC7588012/ /pubmed/33096860 http://dx.doi.org/10.3390/molecules25204864 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Rui
Chen, Yu
Borgard, Heather
Jijiwa, Mayumi
Nasu, Masaki
He, Min
Deng, Youping
The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title_full The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title_fullStr The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title_full_unstemmed The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title_short The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
title_sort function and mechanism of lipid molecules and their roles in the diagnosis and prognosis of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588012/
https://www.ncbi.nlm.nih.gov/pubmed/33096860
http://dx.doi.org/10.3390/molecules25204864
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