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Fast Estimation of the Blood–Brain Barrier Permeability by Pulling a Ligand through a Lipid Membrane
[Image: see text] The blood–brain barrier (BBB) is a physical barrier that regulates the homeostasis of the neural microenvironment. A relative estimate of the BBB permeability, which is important for drug design, may be experimentally provided by the logBB (the blood–brain concentration ratio) and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588033/ https://www.ncbi.nlm.nih.gov/pubmed/32469527 http://dx.doi.org/10.1021/acs.jcim.9b00834 |