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A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling

G protein-coupled receptors (GPCRs) allow cells to respond to chemical and sensory stimuli through generation of second messengers, such as cyclic AMP (cAMP), which in turn mediate a myriad of processes, including cell survival, proliferation, and differentiation. In order to gain deeper insights in...

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Detalles Bibliográficos
Autores principales:	Semesta, Khairunnisa Mentari, Tian, Ruilin, Kampmann, Martin, von Zastrow, Mark, Tsvetanova, Nikoleta G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588078/ https://www.ncbi.nlm.nih.gov/pubmed/33052901 http://dx.doi.org/10.1371/journal.pgen.1009103

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