Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis

[Image: see text] The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda–Grubbs catalyst and its nitro analogue, providing a wide range of substituted pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Woźniak, Łukasz, Rajkiewicz, Adam A., Monsigny, Louis, Kajetanowicz, Anna, Grela, Karol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588130/
https://www.ncbi.nlm.nih.gov/pubmed/32610933
http://dx.doi.org/10.1021/acs.orglett.0c01471
_version_ 1783600318820384768
author Woźniak, Łukasz
Rajkiewicz, Adam A.
Monsigny, Louis
Kajetanowicz, Anna
Grela, Karol
author_facet Woźniak, Łukasz
Rajkiewicz, Adam A.
Monsigny, Louis
Kajetanowicz, Anna
Grela, Karol
author_sort Woźniak, Łukasz
collection PubMed
description [Image: see text] The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda–Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan.
format Online
Article
Text
id pubmed-7588130
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-75881302020-10-27 Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis Woźniak, Łukasz Rajkiewicz, Adam A. Monsigny, Louis Kajetanowicz, Anna Grela, Karol Org Lett [Image: see text] The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda–Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan. American Chemical Society 2020-06-17 2020-07-02 /pmc/articles/PMC7588130/ /pubmed/32610933 http://dx.doi.org/10.1021/acs.orglett.0c01471 Text en This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Woźniak, Łukasz
Rajkiewicz, Adam A.
Monsigny, Louis
Kajetanowicz, Anna
Grela, Karol
Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title_full Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title_fullStr Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title_full_unstemmed Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title_short Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
title_sort preparation of functionalized α,β-unsaturated sulfonamides via olefin cross-metathesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588130/
https://www.ncbi.nlm.nih.gov/pubmed/32610933
http://dx.doi.org/10.1021/acs.orglett.0c01471
work_keys_str_mv AT wozniakłukasz preparationoffunctionalizedabunsaturatedsulfonamidesviaolefincrossmetathesis
AT rajkiewiczadama preparationoffunctionalizedabunsaturatedsulfonamidesviaolefincrossmetathesis
AT monsignylouis preparationoffunctionalizedabunsaturatedsulfonamidesviaolefincrossmetathesis
AT kajetanowiczanna preparationoffunctionalizedabunsaturatedsulfonamidesviaolefincrossmetathesis
AT grelakarol preparationoffunctionalizedabunsaturatedsulfonamidesviaolefincrossmetathesis

Ejemplares similares