APOE2 is associated with longevity independent of Alzheimer’s disease

Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed...

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Detalles Bibliográficos
Autores principales: Shinohara, Mitsuru, Kanekiyo, Takahisa, Tachibana, Masaya, Kurti, Aishe, Shinohara, Motoko, Fu, Yuan, Zhao, Jing, Han, Xianlin, Sullivan, Patrick M, Rebeck, G William, Fryer, John D, Heckman, Michael G, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588231/
https://www.ncbi.nlm.nih.gov/pubmed/33074098
http://dx.doi.org/10.7554/eLife.62199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588231/
https://www.ncbi.nlm.nih.gov/pubmed/33074098
http://dx.doi.org/10.7554/eLife.62199

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