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The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb with multiple pharmacological activities, including the broad anti-virus effects. In this paper, the preclinical study of baicalein on the treatment of COVID-19 was performed. Results showed that baicalein inhi...

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Detalles Bibliográficos
Autores principales: Song, Junke, Zhang, Li, Xu, Yanfeng, Yang, Dezhi, Yang, Shiying, Zhang, Wen, Wang, Jinhua, Tian, Shuo, Yang, Shengqian, Yuan, Tianyi, Liu, Ailin, Lv, Qi, Li, Fengdi, Liu, Hongqi, Hou, Biyu, Peng, Xiaozhong, Lu, Yang, Du, Guanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588320/
https://www.ncbi.nlm.nih.gov/pubmed/33121927
http://dx.doi.org/10.1016/j.bcp.2020.114302
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author Song, Junke
Zhang, Li
Xu, Yanfeng
Yang, Dezhi
Zhang, Li
Yang, Shiying
Zhang, Wen
Wang, Jinhua
Tian, Shuo
Yang, Shengqian
Yuan, Tianyi
Liu, Ailin
Lv, Qi
Li, Fengdi
Liu, Hongqi
Hou, Biyu
Peng, Xiaozhong
Lu, Yang
Du, Guanhua
author_facet Song, Junke
Zhang, Li
Xu, Yanfeng
Yang, Dezhi
Zhang, Li
Yang, Shiying
Zhang, Wen
Wang, Jinhua
Tian, Shuo
Yang, Shengqian
Yuan, Tianyi
Liu, Ailin
Lv, Qi
Li, Fengdi
Liu, Hongqi
Hou, Biyu
Peng, Xiaozhong
Lu, Yang
Du, Guanhua
author_sort Song, Junke
collection PubMed
description Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb with multiple pharmacological activities, including the broad anti-virus effects. In this paper, the preclinical study of baicalein on the treatment of COVID-19 was performed. Results showed that baicalein inhibited cell damage induced by SARS-CoV-2 and improved the morphology of Vero E6 cells at a concentration of 0.1 μM and above. The effective concentration could be reached after oral administration of 200 mg/kg crystal form β of baicalein in rats. Furthermore, baicalein significantly inhibited the body weight loss, the replication of the virus, and relieved the lesions of lung tissue in hACE2 transgenic mice infected with SARS-CoV-2. In LPS-induced acute lung injury of mice, baicalein improved the respiratory function, inhibited inflammatory cell infiltration in the lung, and decreased the levels of IL-1β and TNF-α in serum. In conclusion, oral administration of crystal form β of baicalein could reach its effective concentration against SARS-CoV-2. Baicalein could inhibit SARS-CoV-2-induced injury both in vitro and in vivo. Therefore, baicalein might be a promising therapeutic drug for the treatment of COVID-19.
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spelling pubmed-75883202020-10-27 The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro Song, Junke Zhang, Li Xu, Yanfeng Yang, Dezhi Zhang, Li Yang, Shiying Zhang, Wen Wang, Jinhua Tian, Shuo Yang, Shengqian Yuan, Tianyi Liu, Ailin Lv, Qi Li, Fengdi Liu, Hongqi Hou, Biyu Peng, Xiaozhong Lu, Yang Du, Guanhua Biochem Pharmacol Article Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb with multiple pharmacological activities, including the broad anti-virus effects. In this paper, the preclinical study of baicalein on the treatment of COVID-19 was performed. Results showed that baicalein inhibited cell damage induced by SARS-CoV-2 and improved the morphology of Vero E6 cells at a concentration of 0.1 μM and above. The effective concentration could be reached after oral administration of 200 mg/kg crystal form β of baicalein in rats. Furthermore, baicalein significantly inhibited the body weight loss, the replication of the virus, and relieved the lesions of lung tissue in hACE2 transgenic mice infected with SARS-CoV-2. In LPS-induced acute lung injury of mice, baicalein improved the respiratory function, inhibited inflammatory cell infiltration in the lung, and decreased the levels of IL-1β and TNF-α in serum. In conclusion, oral administration of crystal form β of baicalein could reach its effective concentration against SARS-CoV-2. Baicalein could inhibit SARS-CoV-2-induced injury both in vitro and in vivo. Therefore, baicalein might be a promising therapeutic drug for the treatment of COVID-19. The Author(s). Published by Elsevier Inc. 2021-01 2020-10-27 /pmc/articles/PMC7588320/ /pubmed/33121927 http://dx.doi.org/10.1016/j.bcp.2020.114302 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Song, Junke
Zhang, Li
Xu, Yanfeng
Yang, Dezhi
Zhang, Li
Yang, Shiying
Zhang, Wen
Wang, Jinhua
Tian, Shuo
Yang, Shengqian
Yuan, Tianyi
Liu, Ailin
Lv, Qi
Li, Fengdi
Liu, Hongqi
Hou, Biyu
Peng, Xiaozhong
Lu, Yang
Du, Guanhua
The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title_full The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title_fullStr The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title_full_unstemmed The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title_short The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
title_sort comprehensive study on the therapeutic effects of baicalein for the treatment of covid-19 in vivo and in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588320/
https://www.ncbi.nlm.nih.gov/pubmed/33121927
http://dx.doi.org/10.1016/j.bcp.2020.114302
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