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Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task
Response inhibition as an executive function refers to the ability to suppress inappropriate but prepotent responses. Several brain regions have been implicated in the process underlying inhibitory control, including the cerebellum. The aim of the present study was to explore the role of the cerebel...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588382/ https://www.ncbi.nlm.nih.gov/pubmed/32666284 http://dx.doi.org/10.1007/s12311-020-01165-z |
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author | Mannarelli, Daniela Pauletti, Caterina Petritis, Alessia Delle Chiaie, Roberto Currà, Antonio Trompetto, Carlo Fattapposta, Francesco |
author_facet | Mannarelli, Daniela Pauletti, Caterina Petritis, Alessia Delle Chiaie, Roberto Currà, Antonio Trompetto, Carlo Fattapposta, Francesco |
author_sort | Mannarelli, Daniela |
collection | PubMed |
description | Response inhibition as an executive function refers to the ability to suppress inappropriate but prepotent responses. Several brain regions have been implicated in the process underlying inhibitory control, including the cerebellum. The aim of the present study was to explore the role of the cerebellum in executive functioning, particularly in response inhibition. For this purpose, we transitorily inhibited cerebellar activity by means of cathodal tDCS and studied the effects of this inhibition on ERP components elicited during a Go/NoGo task in healthy subjects. Sixteen healthy subjects underwent a Go/NoGo task prior to and after cathodal and sham cerebellar tDCS in separate sessions. A reduction in N2-NoGo amplitude and a prolongation in N2-NoGo latency emerged after cathodal tDCS whereas no differences were detected after sham stimulation. Moreover, commission errors in NoGo trials were significantly higher after cathodal tDCS than at the basal evaluation. No differences emerged between performances in Go trials and those after sham stimulation. These data indicate that cerebellar inhibition following cathodal stimulation alters the ability to allocate attentional resources to stimuli containing conflict information and the inhibitory control. The cerebellum may regulate the attentional mechanisms of stimulus orientation and inhibitory control both directly, by making predictions of errors or behaviors related to errors, and indirectly, by controlling the functioning of the cerebral cortical areas involved in the perception of conflict signals and of the basal ganglia involved in the inhibitory control of movement. |
format | Online Article Text |
id | pubmed-7588382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-75883822020-10-29 Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task Mannarelli, Daniela Pauletti, Caterina Petritis, Alessia Delle Chiaie, Roberto Currà, Antonio Trompetto, Carlo Fattapposta, Francesco Cerebellum Original Article Response inhibition as an executive function refers to the ability to suppress inappropriate but prepotent responses. Several brain regions have been implicated in the process underlying inhibitory control, including the cerebellum. The aim of the present study was to explore the role of the cerebellum in executive functioning, particularly in response inhibition. For this purpose, we transitorily inhibited cerebellar activity by means of cathodal tDCS and studied the effects of this inhibition on ERP components elicited during a Go/NoGo task in healthy subjects. Sixteen healthy subjects underwent a Go/NoGo task prior to and after cathodal and sham cerebellar tDCS in separate sessions. A reduction in N2-NoGo amplitude and a prolongation in N2-NoGo latency emerged after cathodal tDCS whereas no differences were detected after sham stimulation. Moreover, commission errors in NoGo trials were significantly higher after cathodal tDCS than at the basal evaluation. No differences emerged between performances in Go trials and those after sham stimulation. These data indicate that cerebellar inhibition following cathodal stimulation alters the ability to allocate attentional resources to stimuli containing conflict information and the inhibitory control. The cerebellum may regulate the attentional mechanisms of stimulus orientation and inhibitory control both directly, by making predictions of errors or behaviors related to errors, and indirectly, by controlling the functioning of the cerebral cortical areas involved in the perception of conflict signals and of the basal ganglia involved in the inhibitory control of movement. Springer US 2020-07-14 2020 /pmc/articles/PMC7588382/ /pubmed/32666284 http://dx.doi.org/10.1007/s12311-020-01165-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Mannarelli, Daniela Pauletti, Caterina Petritis, Alessia Delle Chiaie, Roberto Currà, Antonio Trompetto, Carlo Fattapposta, Francesco Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title | Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title_full | Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title_fullStr | Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title_full_unstemmed | Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title_short | Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task |
title_sort | effects of cerebellar tdcs on inhibitory control: evidence from a go/nogo task |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588382/ https://www.ncbi.nlm.nih.gov/pubmed/32666284 http://dx.doi.org/10.1007/s12311-020-01165-z |
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