Osteopontin binds ICOSL promoting tumor metastasis

ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the binding induces a conformational change in OP...

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Detalles Bibliográficos
Autores principales: Raineri, Davide, Dianzani, Chiara, Cappellano, Giuseppe, Maione, Federica, Baldanzi, Gianluca, Iacobucci, Ilaria, Clemente, Nausicaa, Baldone, Giulia, Boggio, Elena, Gigliotti, Casimiro L., Boldorini, Renzo, Rojo, Josè M., Monti, Maria, Birolo, Leila, Dianzani, Umberto, Chiocchetti, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588454/
https://www.ncbi.nlm.nih.gov/pubmed/33106594
http://dx.doi.org/10.1038/s42003-020-01333-1

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