Prediction of the binding interface between monoclonal antibody m102.4 and Nipah attachment glycoprotein using structure-guided alanine scanning and computational docking

Nipah Virus (NiV) has been designated as a priority disease with an urgent need for therapeutic development by World Health Organization. The monoclonal antibody m102.4 binds to the immunodominant NiV receptor-binding glycoprotein (GP), and potently neutralizes NiV, indicating its potential as a the...

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Detalles Bibliográficos
Autores principales: Tit-oon, Phanthakarn, Tharakaraman, Kannan, Artpradit, Charlermchai, Godavarthi, Abhinav, Sungkeeree, Pareenart, Sasisekharan, Varun, Kerdwong, Jarunee, Miller, Nathaniel Loren, Mahajan, Bhuvna, Khongmanee, Amnart, Ruchirawat, Mathuros, Sasisekharan, Ram, Fuangthong, Mayuree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588459/
https://www.ncbi.nlm.nih.gov/pubmed/33106487
http://dx.doi.org/10.1038/s41598-020-75056-y

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