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Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013
We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient’s household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588542/ https://www.ncbi.nlm.nih.gov/pubmed/33079034 http://dx.doi.org/10.3201/eid2611.181418 |
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author | Alvarez, Josep Godoy, Pere Plans-Rubio, Pedro Camps, Neus Carol, Monica Carmona, Gloria Solano, Ruben Rius, Cristina Minguell, Sofia Barrabeig, Irene Sala-Farré, Maria R. Rodriguez, Raquel Garcia-Cenoz, Manuel Muñoz-Almagro, Carmen Dominguez, Angela |
author_facet | Alvarez, Josep Godoy, Pere Plans-Rubio, Pedro Camps, Neus Carol, Monica Carmona, Gloria Solano, Ruben Rius, Cristina Minguell, Sofia Barrabeig, Irene Sala-Farré, Maria R. Rodriguez, Raquel Garcia-Cenoz, Manuel Muñoz-Almagro, Carmen Dominguez, Angela |
author_sort | Alvarez, Josep |
collection | PubMed |
description | We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient’s household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8–14 days, 15–21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient’s symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient’s symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient’s symptom onset. |
format | Online Article Text |
id | pubmed-7588542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-75885422020-11-01 Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 Alvarez, Josep Godoy, Pere Plans-Rubio, Pedro Camps, Neus Carol, Monica Carmona, Gloria Solano, Ruben Rius, Cristina Minguell, Sofia Barrabeig, Irene Sala-Farré, Maria R. Rodriguez, Raquel Garcia-Cenoz, Manuel Muñoz-Almagro, Carmen Dominguez, Angela Emerg Infect Dis Research We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient’s household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8–14 days, 15–21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient’s symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient’s symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient’s symptom onset. Centers for Disease Control and Prevention 2020-11 /pmc/articles/PMC7588542/ /pubmed/33079034 http://dx.doi.org/10.3201/eid2611.181418 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Alvarez, Josep Godoy, Pere Plans-Rubio, Pedro Camps, Neus Carol, Monica Carmona, Gloria Solano, Ruben Rius, Cristina Minguell, Sofia Barrabeig, Irene Sala-Farré, Maria R. Rodriguez, Raquel Garcia-Cenoz, Manuel Muñoz-Almagro, Carmen Dominguez, Angela Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title_full | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title_fullStr | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title_full_unstemmed | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title_short | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013 |
title_sort | azithromycin to prevent pertussis in household contacts, catalonia and navarre, spain, 2012–2013 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588542/ https://www.ncbi.nlm.nih.gov/pubmed/33079034 http://dx.doi.org/10.3201/eid2611.181418 |
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