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Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients

OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. st...

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Autores principales: Liu, Jiachang, Wang, Ruikai, Fang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588764/
https://www.ncbi.nlm.nih.gov/pubmed/33081537
http://dx.doi.org/10.1177/0300060520962296
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author Liu, Jiachang
Wang, Ruikai
Fang, Ming
author_facet Liu, Jiachang
Wang, Ruikai
Fang, Ming
author_sort Liu, Jiachang
collection PubMed
description OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. stuartii infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the P. stuartii isolates were recorded. RESULTS: Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of P. stuartii. Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. P. stuartii isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died. CONCLUSIONS: Drug resistance is increasing in P. stuartii. The antimicrobial agent imipenem may be effective for treatment of P. stuartii infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy.
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spelling pubmed-75887642020-11-09 Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients Liu, Jiachang Wang, Ruikai Fang, Ming J Int Med Res Retrospective Clinical Research Report OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. stuartii infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the P. stuartii isolates were recorded. RESULTS: Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of P. stuartii. Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. P. stuartii isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died. CONCLUSIONS: Drug resistance is increasing in P. stuartii. The antimicrobial agent imipenem may be effective for treatment of P. stuartii infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy. SAGE Publications 2020-10-20 /pmc/articles/PMC7588764/ /pubmed/33081537 http://dx.doi.org/10.1177/0300060520962296 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Liu, Jiachang
Wang, Ruikai
Fang, Ming
Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title_full Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title_fullStr Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title_full_unstemmed Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title_short Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
title_sort clinical and drug resistance characteristics of providencia stuartii infections in 76 patients
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588764/
https://www.ncbi.nlm.nih.gov/pubmed/33081537
http://dx.doi.org/10.1177/0300060520962296
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