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Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients
OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588764/ https://www.ncbi.nlm.nih.gov/pubmed/33081537 http://dx.doi.org/10.1177/0300060520962296 |
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author | Liu, Jiachang Wang, Ruikai Fang, Ming |
author_facet | Liu, Jiachang Wang, Ruikai Fang, Ming |
author_sort | Liu, Jiachang |
collection | PubMed |
description | OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. stuartii infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the P. stuartii isolates were recorded. RESULTS: Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of P. stuartii. Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. P. stuartii isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died. CONCLUSIONS: Drug resistance is increasing in P. stuartii. The antimicrobial agent imipenem may be effective for treatment of P. stuartii infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy. |
format | Online Article Text |
id | pubmed-7588764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75887642020-11-09 Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients Liu, Jiachang Wang, Ruikai Fang, Ming J Int Med Res Retrospective Clinical Research Report OBJECTIVES: To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. METHODS: This single-center retrospective analysis included 76 patients with P. stuartii infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the P. stuartii isolates were recorded. RESULTS: Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of P. stuartii. Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. P. stuartii isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died. CONCLUSIONS: Drug resistance is increasing in P. stuartii. The antimicrobial agent imipenem may be effective for treatment of P. stuartii infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy. SAGE Publications 2020-10-20 /pmc/articles/PMC7588764/ /pubmed/33081537 http://dx.doi.org/10.1177/0300060520962296 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Liu, Jiachang Wang, Ruikai Fang, Ming Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title | Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title_full | Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title_fullStr | Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title_full_unstemmed | Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title_short | Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients |
title_sort | clinical and drug resistance characteristics of providencia stuartii infections in 76 patients |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588764/ https://www.ncbi.nlm.nih.gov/pubmed/33081537 http://dx.doi.org/10.1177/0300060520962296 |
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